Finamore, Claudia (2017) Semisynthetic bile acid derivatives as human receptor modulators. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Semisynthetic bile acid derivatives as human receptor modulators
Creators:
CreatorsEmail
Finamore, Claudiaclaudia.finamore@unina.it
Date: 9 April 2017
Number of Pages: 268
Institution: Università degli Studi di Napoli Federico II
Department: Farmacia
Dottorato: Scienza del farmaco
Ciclo di dottorato: 29
Coordinatore del Corso di dottorato:
nomeemail
D'Auria, Maria Valeriamadauria@unina.it
Tutor:
nomeemail
Sepe, ValentinaUNSPECIFIED
Date: 9 April 2017
Number of Pages: 268
Uncontrolled Keywords: bile acids
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/06 - Chimica organica
Date Deposited: 26 Apr 2017 21:22
Last Modified: 13 Mar 2018 12:05
URI: http://www.fedoa.unina.it/id/eprint/11715
DOI: 10.6093/UNINA/FEDOA/11715

Abstract

Bile acids (BAs) are considered signaling molecules able to interact with nuclear and membrane endogenous receptors, inducing several cellular networks that regulate lipids, glucose and bile acids homeostasis. Two well-known targets of BAs are the endogenous nuclear receptor FXR (farnesoid-x-receptor) and the membrane receptor GPBAR1 (G-protein coupled receptor 1) and since their activation is linked to the control of different metabolic and enterohepatic functions, they could be considered efficient targets in the treatment of several human diseases. In the last few years, medicinal chemistry modifications on bile acid scaffolds, afforded a large amount of exogenous derivatives with different pharmacological profiles, useful in the treatment of metabolic and enterohepatic disorders, ranging from metabolic syndrome, diabetes, cholestasis and non-alcoholic steatohepatitis

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