Del Franco, Mariateresa (2017) Genomic epidemiology of multi-drug resistant Acinetobacter baumannii: characterization of antibiotic resistant determinants and virulence features of successful resistant clonal lineages. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Genomic epidemiology of multi-drug resistant Acinetobacter baumannii: characterization of antibiotic resistant determinants and virulence features of successful resistant clonal lineages |
| Autori: | Autore Email Del Franco, Mariateresa mariateresa.88@libero.it |
| Data: | 4 Ottobre 2017 |
| Numero di pagine: | 63 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Sanità Pubblica |
| Dottorato: | Sanità pubblica e medicina preventiva |
| Ciclo di dottorato: | 29 |
| Coordinatore del Corso di dottorato: | nome email Montagnani, Stefania stefania.montagnani@unina.it |
| Tutor: | nome email Zarrilli, Raffaele [non definito] |
| Data: | 4 Ottobre 2017 |
| Numero di pagine: | 63 |
| Parole chiave: | Acinetobacter baumannii; multi-drug resistant; clonal lineages; virulence features |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare Area 06 - Scienze mediche > MED/42 - Igiene generale e applicat |
| Depositato il: | 19 Ott 2017 07:28 |
| Ultima modifica: | 13 Mar 2018 11:53 |
| URI: | http://www.fedoa.unina.it/id/eprint/11876 |
| DOI: | 10.6093/UNINA/FEDOA/11876 |
Abstract
Acinetobacter baumannii is a globally important nosocomial pathogen associated with clinical infections that are difficult to treat due to broad antimicrobial resistance. A. baumannii epidemics are caused by a limited number of strains worldwide, belonging to the initially named European clones, but now regarded to as International clonal lineages (IC) I, II and III and a few additional lineages recently emerged as epidemic clones in some regions, such as the sequence types (ST)10, ST15, ST25, ST78 and ST79 according to Pasteur’s multilocus sequencing typing (MLST) scheme. The spread of extensively drug-resistant (XDR) gram-negative bacteria has boosted colistin use, with a resultant selection of colistin-resistant, often pandrug-resistant strains. In addition to extensively antimicrobial resistance, A. baumannii strains responsible for epidemics show elevated resistance to desiccation, high biofilm-forming capacity on abiotic surfaces and adherence to host epithelial cells, virulence-related features which might have favored the spread and persistence in the hospital environment.As in other microrganisms, the formation of biofilm in A. baumannii is a redundantly organized, multifactorial process involving multiple cellular components.The above data suggest that multiple proteins sharing Ig-like repeats contribute to biofilm formation in Acinetobacter species.
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