Del Franco, Mariateresa (2017) Genomic epidemiology of multi-drug resistant Acinetobacter baumannii: characterization of antibiotic resistant determinants and virulence features of successful resistant clonal lineages. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Genomic epidemiology of multi-drug resistant Acinetobacter baumannii: characterization of antibiotic resistant determinants and virulence features of successful resistant clonal lineages
Creators:
CreatorsEmail
Del Franco, Mariateresamariateresa.88@libero.it
Date: 4 October 2017
Number of Pages: 63
Institution: Università degli Studi di Napoli Federico II
Department: Sanità Pubblica
Dottorato: Sanità pubblica e medicina preventiva
Ciclo di dottorato: 29
Coordinatore del Corso di dottorato:
nomeemail
Montagnani, Stefaniastefania.montagnani@unina.it
Tutor:
nomeemail
Zarrilli, RaffaeleUNSPECIFIED
Date: 4 October 2017
Number of Pages: 63
Uncontrolled Keywords: Acinetobacter baumannii; multi-drug resistant; clonal lineages; virulence features
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare
Area 06 - Scienze mediche > MED/42 - Igiene generale e applicat
Date Deposited: 19 Oct 2017 07:28
Last Modified: 13 Mar 2018 11:53
URI: http://www.fedoa.unina.it/id/eprint/11876
DOI: 10.6093/UNINA/FEDOA/11876

Abstract

Acinetobacter baumannii is a globally important nosocomial pathogen associated with clinical infections that are difficult to treat due to broad antimicrobial resistance. A. baumannii epidemics are caused by a limited number of strains worldwide, belonging to the initially named European clones, but now regarded to as International clonal lineages (IC) I, II and III and a few additional lineages recently emerged as epidemic clones in some regions, such as the sequence types (ST)10, ST15, ST25, ST78 and ST79 according to Pasteur’s multilocus sequencing typing (MLST) scheme. The spread of extensively drug-resistant (XDR) gram-negative bacteria has boosted colistin use, with a resultant selection of colistin-resistant, often pandrug-resistant strains. In addition to extensively antimicrobial resistance, A. baumannii strains responsible for epidemics show elevated resistance to desiccation, high biofilm-forming capacity on abiotic surfaces and adherence to host epithelial cells, virulence-related features which might have favored the spread and persistence in the hospital environment.As in other microrganisms, the formation of biofilm in A. baumannii is a redundantly organized, multifactorial process involving multiple cellular components.The above data suggest that multiple proteins sharing Ig-like repeats contribute to biofilm formation in Acinetobacter species.

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