Bianco, Simona (2017) Polymer physics models of the chromatin spatial organization in the cell nucleus. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Polymer physics models of the chromatin spatial organization in the cell nucleus |
| Autori: | Autore Email Bianco, Simona biancos@na.infn.it |
| Data: | 9 Dicembre 2017 |
| Numero di pagine: | 96 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | dep06 |
| Dottorato: | phd028 |
| Ciclo di dottorato: | 30 |
| Coordinatore del Corso di dottorato: | nome email Capozziello, Salvatore capozzie@na.infn.it |
| Tutor: | nome email Nicodemi, Mario [non definito] |
| Data: | 9 Dicembre 2017 |
| Numero di pagine: | 96 |
| Parole chiave: | polymer physics, chromatin |
| Settori scientifico-disciplinari del MIUR: | Area 02 - Scienze fisiche > FIS/02 - Fisica teorica, modelli e metodi matematici |
| Depositato il: | 17 Gen 2018 09:26 |
| Ultima modifica: | 02 Apr 2019 11:02 |
| URI: | http://www.fedoa.unina.it/id/eprint/12114 |
Abstract
This PhD thesis concerns the application of polymer physics to investigate the mechanisms underlying the 3D organization of chromosomes in mammalian genomes. Chromosome architecture has in fact a crucial role in vital biological functions and its abnormal folding is often linked to severe human diseases. Yet, a unified quantitative framework describing the spatial chromatin organization is still lacking. The polymer models developed in this work allow to obtain highly accurate 3D reconstructions of specific genomic regions and have been employed in particular to predict the effects on chromosome structure of genetic rearrangements, such as deletions, insertions and duplications, often linked to diseases.
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