Bianco, Simona (2017) Polymer physics models of the chromatin spatial organization in the cell nucleus. [Tesi di dottorato]
Preview |
Text
Bianco_Simona_30.pdf Download (27MB) | Preview |
| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | Polymer physics models of the chromatin spatial organization in the cell nucleus |
| Creators: | Creators Email Bianco, Simona biancos@na.infn.it |
| Date: | 9 December 2017 |
| Number of Pages: | 96 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | dep06 |
| Dottorato: | phd028 |
| Ciclo di dottorato: | 30 |
| Coordinatore del Corso di dottorato: | nome email Capozziello, Salvatore capozzie@na.infn.it |
| Tutor: | nome email Nicodemi, Mario UNSPECIFIED |
| Date: | 9 December 2017 |
| Number of Pages: | 96 |
| Keywords: | polymer physics, chromatin |
| Settori scientifico-disciplinari del MIUR: | Area 02 - Scienze fisiche > FIS/02 - Fisica teorica, modelli e metodi matematici |
| Date Deposited: | 17 Jan 2018 09:26 |
| Last Modified: | 02 Apr 2019 11:02 |
| URI: | http://www.fedoa.unina.it/id/eprint/12114 |
Collection description
This PhD thesis concerns the application of polymer physics to investigate the mechanisms underlying the 3D organization of chromosomes in mammalian genomes. Chromosome architecture has in fact a crucial role in vital biological functions and its abnormal folding is often linked to severe human diseases. Yet, a unified quantitative framework describing the spatial chromatin organization is still lacking. The polymer models developed in this work allow to obtain highly accurate 3D reconstructions of specific genomic regions and have been employed in particular to predict the effects on chromosome structure of genetic rearrangements, such as deletions, insertions and duplications, often linked to diseases.
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |
