De Fenza, Maria (2018) Selectivity of biomolecular recognition processes: synthesis and pharmacological activity of novel biomimetic agents. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: Selectivity of biomolecular recognition processes: synthesis and pharmacological activity of novel biomimetic agents.
Creators:
CreatorsEmail
De Fenza, Mariamaria.defenza@unina.it
Date: 19 December 2018
Number of Pages: 188
Institution: Università degli Studi di Napoli Federico II
Department: Scienze Chimiche
Dottorato: Scienze chimiche
Ciclo di dottorato: 31
Coordinatore del Corso di dottorato:
nomeemail
Paduano, Luigiluigi.paduano@unina.it
Tutor:
nomeemail
Guaragna, AnnalisaUNSPECIFIED
Date: 19 December 2018
Number of Pages: 188
Uncontrolled Keywords: Glycomimetics; iminosugars; rare diseases; nucleoside analogues; antiviral agents; modified oligonucleotides; preorganized nucleic acids.
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/06 - Chimica organica
Date Deposited: 19 Jan 2019 16:24
Last Modified: 16 Jun 2020 10:07
URI: http://www.fedoa.unina.it/id/eprint/12711

Abstract

Biomimetic agents are synthetic compounds devised to resemble structures and properties of natural biomolecules with the aim to solve complex human problems. Glycomimetics, nucleoside analogues (NAs) and modified oligonucleotides (MOs) represent biomimetic agents that have found various pharmacological applications and constitute the topic of the three main sections in which this PhD thesis has been organized. The design, the synthesis and then the biological evaluation of such molecules have been undertaken; in all cases the aim was the development of new agents with targeted pharmacological activity or improved biological selectivity in several medicinal chemistry contexts.

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