Scala, Emanuele (2020) A new TH17 cytokine in hidradenitis suppurativa: antimicrobial and pro-inflammatory role of IL-26. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Lingua: English
Title: A new TH17 cytokine in hidradenitis suppurativa: antimicrobial and pro-inflammatory role of IL-26
Creators:
CreatorsEmail
Scala, Emanueleemanuele.scala@outlook.com
Date: 4 March 2020
Number of Pages: 37
Institution: Università degli Studi di Napoli Federico II
Department: Medicina Clinica e Chirurgia
Dottorato: Medicina clinica e sperimentale
Ciclo di dottorato: 32
Coordinatore del Corso di dottorato:
nomeemail
Beguinot, Francescobeguino@unina.it
Tutor:
nomeemail
Balato, AnnaUNSPECIFIED
Date: 4 March 2020
Number of Pages: 37
Uncontrolled Keywords: Hidradenitis suppurativa, interleukin-26, antimicrobial peptides, inflammation
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/35 - Malattie cutanee e veneree
Date Deposited: 26 Mar 2020 12:07
Last Modified: 17 Nov 2021 10:30
URI: http://www.fedoa.unina.it/id/eprint/13004

Abstract

Interleukin (IL)-26 is a member of the IL-10 cytokine family which includes IL-10, IFN-λs (IL-28A/B and IL-29), and the IL-20 subfamily (IL-19, IL-20, IL-22, IL-24, and IL-26). It is mainly expressed in Th17 cells and plays a dual role. Indeed, IL-26 is a pro-inflammatory cytokine that exerts antimicrobial response producing direct bactericidal action through affecting the formation of membrane pores. IL-26 acts through IL-10R2/IL-20R1 heterodimeric receptor. While IL-10R2 is broadly expressed, IL-20R1 is mainly expressed by epithelial cell types, including keratinocytes, suggesting its possible role in the immune response of the skin. To date, IL-26 has been implicated in psoriasis and allergic contact dermatitis (ACD). In particular, IL-26 contribute to the cytotoxic mechanism, proper of ACD. This mechanism is responsible for the tissue injury of immune-mediated skin diseases, including Hidradenitis Suppurativa (HS). The latter is characterized by recurrent, painful, nodules and abscesses that break, leading to the formation of sinus tracts and scarring. Lesions usually affect apocrine gland-bearing anatomical areas of the body involving build-up of keratin within the hair follicle that plugs the follicle causing the occlusion and subsequent rupture of pilosebaceous unit. Morever, colonies of specialized bacteria (mainly, staphylococci and streptococci) bind irreversibly to sinus tract epithelium and hair follicles, further sustaining chronic inflammation. In this study, we have evaluated IL-26 in HS exploring its antimicrobial activity.

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