Esposito, Diletta
(2020)
Advanced strategies to deliver bioactive molecules in nutraceuticals.
[Tesi di dottorato]
| Tipologia del documento: |
Tesi di dottorato
|
| Lingua: |
English |
| Titolo: |
Advanced strategies to deliver bioactive molecules in nutraceuticals |
| Autori: |
| Autore | Email |
|---|
| Esposito, Diletta | diletta.esposito@unina.it |
|
| Data: |
5 Marzo 2020 |
| Numero di pagine: |
186 |
| Istituzione: |
Università degli Studi di Napoli Federico II |
| Dipartimento: |
Farmacia |
| Dottorato: |
Scienza del farmaco |
| Ciclo di dottorato: |
32 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| D'Auria, Maria Valeria | madauria@unina.it |
|
| Tutor: |
| nome | email |
|---|
| Quaglia, Fabiana | [non definito] |
|
| Data: |
5 Marzo 2020 |
| Numero di pagine: |
186 |
| Parole chiave: |
zein;beta-cyclodextrin;iron bisglycinate;curcumin;spray-drying; powders;food supplements;nutraceuticals |
| Settori scientifico-disciplinari del MIUR: |
Area 03 - Scienze chimiche > CHIM/09 - Farmaceutico tecnologico applicativo |
[error in script]
[error in script]
| Depositato il: |
19 Mar 2020 11:22 |
| Ultima modifica: |
10 Nov 2021 14:32 |
| URI: |
http://www.fedoa.unina.it/id/eprint/13009 |
Abstract
Nowadays, nutraceuticals have become increasingly popular due to their potential nutritional and physiological effects. They may be used to improve health, delay the aging process, prevent chronic diseases, increase life expectancy, or support the structure or function of the body. Recently, the scientific community has been not only focused on the beneficial properties of nutraceuticals but also the optimization of their delivery in the body. This aspect is crucial to overcome the hurdles to their oral absorption and preserve their effect on human health.
In this scenario, there has been a growing interest in the design of delivery systems able to enhance their nutritional potential.
Herein, we report the development of oral delivery platforms for both a lipophilic (curcumin) and a hydrophilic compound (iron bisglycinate) with implemented properties and potentially transferable to an industrial setting. The strategy encompasses the combined use of zein, a plant-based protein extracted from corn, with beta-cyclodextrin (beta-CD) and the processing through nano/microtechnologies. An appropriate set-up of the experimental parameters allowed the fabrication of nanoparticles that can be used either as liquid formulation or as micropowders after spray-drying. All the systems were fully characterized through a large panel of techniques. Beta-CD held a crucial role in the formulation process due to its ability to form host-guest inclusion complexes with both zein and bioactive compounds. The remarkable interaction of the particles with mucus was useful to extend their residence time in the gastrointestinal tract and prospectively to improve absorption of the bioactive cargo.
Overall, zein/beta-CD platforms can be considered as a novel tool for efficient oral delivery of nutraceutical compounds in the body, which could be potentially used in functional foods and dietary supplements.
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