Micillo, Teresa
(2020)
Impact of dimethyl fumarate treatment on immune tolerance during Multiple Sclerosis.
[Tesi di dottorato]
| Tipologia del documento: |
Tesi di dottorato
|
| Lingua: |
English |
| Titolo: |
Impact of dimethyl fumarate treatment on immune tolerance during Multiple Sclerosis |
| Autori: |
| Autore | Email |
|---|
| Micillo, Teresa | ter.micillo@gmail.com |
|
| Data: |
2020 |
| Numero di pagine: |
56 |
| Istituzione: |
Università degli Studi di Napoli Federico II |
| Dipartimento: |
Biologia |
| Dottorato: |
Biologia |
| Ciclo di dottorato: |
32 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| Cozzolino, Salvatore | cozzolin@unina.it |
|
| Tutor: |
| nome | email |
|---|
| Porcellini, Antonio | [non definito] |
|
| Data: |
2020 |
| Numero di pagine: |
56 |
| Parole chiave: |
Immunology, Dimethyl fumarate,
Multiple Sclerosis. |
| Settori scientifico-disciplinari del MIUR: |
Area 06 - Scienze mediche > MED/04 - Patologia generale |
[error in script]
[error in script]
| Depositato il: |
26 Mar 2020 08:34 |
| Ultima modifica: |
08 Nov 2021 12:23 |
| URI: |
http://www.fedoa.unina.it/id/eprint/13130 |
Abstract
Dimethyl fumarate (DMF) is a first line oral treatment for relapsing-remitting multiple sclerosis (RR-MS) patients. Although it is known that DMF have protective antioxidant properties against brain and spinal cord damage during MS, its precise mechanism of action remains still elusive. Here, we evaluated the immunological effects of DMF treatment in RR-MS patients and we investigated the impact of DMF on metabolic profile of T cells. We observed that DMF treatment results in reduction of number of total lymphocytes and of CD19+ B cells, CD4+ and CD8+ T cells.
In addition, DMF treatment is associated with a specific reduction of the memory T cells. Furthermore, we found that DMF treatment was able to increase the proliferative capacity of Treg cells over time and to restore the altered metabolic profile of T cells in RR-MS patients. Taken together, these data suggest a novel mechanism of action for DMF by modulation of the metabolic pathways of T cells that could lead to an improvement of immune tolerance during autoimmunity.
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