Saccà, Carmen Daniela (2020) Role of the histone demethylase LSD1 in Brain Tumor. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Role of the histone demethylase LSD1 in Brain Tumor |
| Autori: | Autore Email Saccà, Carmen Daniela carmendaniela.sacca@unina.it |
| Data: | 13 Marzo 2020 |
| Numero di pagine: | 73 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Biologia |
| Dottorato: | Biologia |
| Ciclo di dottorato: | 32 |
| Coordinatore del Corso di dottorato: | nome email Cozzolino, Salvatore salvatore.cozzolino@unina.it |
| Tutor: | nome email Majello, Barbara [non definito] |
| Data: | 13 Marzo 2020 |
| Numero di pagine: | 73 |
| Parole chiave: | BRAIN TUMOR/ LSD1/ EPIGENETIC THERAPY / Epithelial-mesenchymal-Transition (EMT)/ Autophagy/ Senescence |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/18 - Genetica |
| Depositato il: | 26 Mar 2020 08:34 |
| Ultima modifica: | 08 Nov 2021 12:20 |
| URI: | http://www.fedoa.unina.it/id/eprint/13137 |
Abstract
Epigenetic enzymes are promising targets for cancer therapy due to their involvement in cellular processes leading to oncogenesis. Accordingly, a number of epi-drugs are currently under investigation. Lysine-specific demethylase 1 (LSD1) removes mono- and di-methylated groups from lysines 4 or 9 on histone H3, via a flavin adenine dinucleotide (FAD)-dependent oxidative reaction. In brain tumours, LSD1 is over-expressed and it is correlated with aggressive disease, suggesting that its inhibition might be considered as therapeutically relevant. The work done during my PHD has been focused on the understanding the role of LSD1 uncovering its potential functions as new potential therapeutic agent for neuroblastoma (NB) and glioblastoma (GBM) tumours. We have investigated on its role in different Brain tumours demonstrating that LSD1 depletion is involved in three tumour-associated pathways: Epithelial-mesenchymal-Transition (EMT); Autophagy and Senescence and that different pathways are affected in different Brain tumours. In conclusion, we propose that pharmacological targeting of LSD1 by small molecules could modulate autophagy, senescence, migration capability and invasiveness of cancer cells through targeting proteins and thus impairing the ability of cancers to metastasize.
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