Saccà, Carmen Daniela (2020) Role of the histone demethylase LSD1 in Brain Tumor. [Tesi di dottorato]


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Item Type: Tesi di dottorato
Lingua: English
Title: Role of the histone demethylase LSD1 in Brain Tumor
Saccà, Carmen
Date: 13 March 2020
Number of Pages: 73
Institution: Università degli Studi di Napoli Federico II
Department: Biologia
Dottorato: Biologia
Ciclo di dottorato: 32
Coordinatore del Corso di dottorato:
Majello, BarbaraUNSPECIFIED
Date: 13 March 2020
Number of Pages: 73
Uncontrolled Keywords: BRAIN TUMOR/ LSD1/ EPIGENETIC THERAPY / Epithelial-mesenchymal-Transition (EMT)/ Autophagy/ Senescence
Settori scientifico-disciplinari del MIUR: Area 05 - Scienze biologiche > BIO/18 - Genetica
Date Deposited: 26 Mar 2020 08:34
Last Modified: 08 Nov 2021 12:20


Epigenetic enzymes are promising targets for cancer therapy due to their involvement in cellular processes leading to oncogenesis. Accordingly, a number of epi-drugs are currently under investigation. Lysine-specific demethylase 1 (LSD1) removes mono- and di-methylated groups from lysines 4 or 9 on histone H3, via a flavin adenine dinucleotide (FAD)-dependent oxidative reaction. In brain tumours, LSD1 is over-expressed and it is correlated with aggressive disease, suggesting that its inhibition might be considered as therapeutically relevant. The work done during my PHD has been focused on the understanding the role of LSD1 uncovering its potential functions as new potential therapeutic agent for neuroblastoma (NB) and glioblastoma (GBM) tumours. We have investigated on its role in different Brain tumours demonstrating that LSD1 depletion is involved in three tumour-associated pathways: Epithelial-mesenchymal-Transition (EMT); Autophagy and Senescence and that different pathways are affected in different Brain tumours. In conclusion, we propose that pharmacological targeting of LSD1 by small molecules could modulate autophagy, senescence, migration capability and invasiveness of cancer cells through targeting proteins and thus impairing the ability of cancers to metastasize.


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