Tufano, Rossella (2020) Evaluation of motility and proliferation of transformed cell lines by computational analysis and in silico simulation. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Evaluation of motility and proliferation of transformed cell lines by computational analysis and in silico simulation |
| Autori: | Autore Email Tufano, Rossella rossella.tufano@unina.it |
| Data: | 13 Marzo 2020 |
| Numero di pagine: | 69 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Medicina Molecolare e Biotecnologie Mediche |
| Dottorato: | Medicina molecolare e biotecnologie mediche |
| Ciclo di dottorato: | 32 |
| Coordinatore del Corso di dottorato: | nome email Avvedimento, Vittorio Enrico vittorioenrico.avvedimento@unina.it |
| Tutor: | nome email Paolella, Giovanni [non definito] |
| Data: | 13 Marzo 2020 |
| Numero di pagine: | 69 |
| Parole chiave: | cell migration; motion models; movement regulation |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/10 - Biochimica |
| Depositato il: | 25 Mar 2020 12:00 |
| Ultima modifica: | 05 Nov 2021 11:47 |
| URI: | http://www.fedoa.unina.it/id/eprint/13208 |
Abstract
Cell migration plays a crucial role in different pathological conditions, so a good understanding of the intra and extra cellular mechanisms involved could help in the development of new therapeutical strategies. Time-lapse microscopy is an excellent tool for dynamically studying cell movement. This work reports the development and testing of an integrated analysis environment based on MotoCell, a web application able to simultaneously manage time-lapse experiments, perform comparative analysis of multiple experiments extracting movement parameters, test models describing cell movement and proliferation and simulate the behaviour of cells growing on Petri dish via a simulation tool able to reproduce and predict the behaviour of cultured cells. The system includes additional tools that deal with acquisition and analysis of microscopy images and graphical representation of datasets containing cell paths obtained by tracking procedures.
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