SGAMBATO, CINZIA
(2021)
Design and fabrication of microfluidic in vitro platforms to study drug delivery systems with bioelectronics sensor OECTs.
[Tesi di dottorato]
| Item Type: |
Tesi di dottorato
|
| Lingua: |
English |
| Title: |
Design and fabrication of microfluidic in vitro platforms to study drug delivery systems with bioelectronics sensor OECTs. |
| Creators: |
| Creators | Email |
|---|
| SGAMBATO, CINZIA | cinziasgambato@gmail.com |
|
| Date: |
15 July 2021 |
| Number of Pages: |
179 |
| Institution: |
Università degli Studi di Napoli Federico II |
| Department: |
Ingegneria Chimica, dei Materiali e della Produzione Industriale |
| Dottorato: |
Ingegneria dei prodotti e dei processi industriali |
| Ciclo di dottorato: |
33 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| D'Anna, Andrea | anddanna@unina.it |
|
| Tutor: |
| nome | email |
|---|
| Netti, Paolo Antonio | UNSPECIFIED | | Vecchione, Raffaele | UNSPECIFIED |
|
| Date: |
15 July 2021 |
| Number of Pages: |
179 |
| Uncontrolled Keywords: |
OECT, microfluidic, drug delivery |
| Settori scientifico-disciplinari del MIUR: |
Area 09 - Ingegneria industriale e dell'informazione > ING-IND/06 - Fluidodinamica
Area 09 - Ingegneria industriale e dell'informazione > ING-IND/34 - Bioingegneria industriale |
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| Date Deposited: |
20 Jul 2021 12:07 |
| Last Modified: |
07 Jun 2023 11:26 |
| URI: |
http://www.fedoa.unina.it/id/eprint/13591 |
Abstract
Electrical impedance sensing of biological systems is now a common technique to monitor cell motion, morphology, and cell layer/tissue integrity for high throughput toxicology screening. Existing methods to measure electrical impedance most often rely on a two or four electrode configuration, where low frequency signals are challenging to obtain for small devices and for tissues with high resistance, due to low current.
Here, we propose a microfluidic PDMS platform integrated with an array of organic electrochemical transistor (OECT) that will allow us to monitor the transendothelial electrical resistance (TEER) with sensitivity higher than the one achieved using common electrode configurations. This platform may have potential as a method for the measurement of compound toxicology in vitro and for diagnostics.
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