Jamaledin, Rezvan (2021) Controlled release of bacteriophage from PLGA microparticles included in fully implantable bicompartmental polymeric microneedles to induce the innate and adaptive immune system response. [Tesi di dottorato]
Anteprima |
Testo
Rezvan_Jamaledin_33.pdf Download (4MB) | Anteprima |
| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Controlled release of bacteriophage from PLGA microparticles included in fully implantable bicompartmental polymeric microneedles to induce the innate and adaptive immune system response |
| Autori: | Autore Email Jamaledin, Rezvan jamaledinrezvan@gmail.com |
| Data: | 12 Luglio 2021 |
| Numero di pagine: | 106 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Ingegneria Chimica, dei Materiali e della Produzione Industriale |
| Dottorato: | Ingegneria dei prodotti e dei processi industriali |
| Ciclo di dottorato: | 33 |
| Coordinatore del Corso di dottorato: | nome email D'Anna, Andrea [non definito] |
| Tutor: | nome email Raffaele, Vecchione [non definito] Antonio Netti, Paolo [non definito] |
| Data: | 12 Luglio 2021 |
| Numero di pagine: | 106 |
| Parole chiave: | PLGA microparticles, polymeric microneedles |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/05 - Scienza e tecnologia dei materiali polimerici |
| Depositato il: | 29 Lug 2021 20:30 |
| Ultima modifica: | 07 Giu 2023 10:41 |
| URI: | http://www.fedoa.unina.it/id/eprint/13689 |
Abstract
The increasing demand for patient-compliance therapies in recent years has led to the development of intradermal and transdermal drug/vaccine delivery, which has several superiorities as compared to conventional methods. This research project endeavored to successfully encapsulate filamentous bacteriophage (Fd) into a Poly(lactic-co-glycolic acid)-based microparticulate system (PLGA MPs). The release profile of these microparticles suggests that they could be used to successfully induce immune and adaptive system. It was the first time that filamentous bacteriophages have been encapsulated in PLGA. The present study also devised a microneedle (MNs) system. A multi compartment microneedles (MNs) system was validated for a number of actives encapsulation (ex. laccase, collagenase) during the PhD activity and upon this optimization the system has been coupled with pillars as a strong mechanical pedestal to increase insertion ability. At the moment, in vivo intradermal delivery from MPs and MNs encapsulated bacteriophages are under investigation. Aside from the development of bacteriophage delivery systems, novel work in the application of fd-bacteriophage was completed with extremely successful results.
Downloads
Downloads per month over past year
Actions (login required)
 |
Modifica documento |
