Pizzorusso, Vincenzo (2021) Relationship between explore to the environmental toxicant methylmercury and the transcriptional repressor rest in vitro model of amyotrophic lateral sclerosis. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Relationship between explore to the environmental toxicant methylmercury and the transcriptional repressor rest in vitro model of amyotrophic lateral sclerosis |
| Autori: | Autore Email Pizzorusso, Vincenzo vpizzorusso@libero.it |
| Data: | 22 Aprile 2021 |
| Numero di pagine: | 110 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Neuroscienze e Scienze Riproduttive ed Odontostomatologiche |
| Dottorato: | Neuroscienze |
| Ciclo di dottorato: | 33 |
| Coordinatore del Corso di dottorato: | nome email TAGLIALATELA, MAURIZIO maurizio.taglialatela@unina.it |
| Tutor: | nome email FORMISANO, LUIGI [non definito] |
| Data: | 22 Aprile 2021 |
| Numero di pagine: | 110 |
| Parole chiave: | METHYLMERCURY, AMYOTROPHIC LATERAL SCLEROSIS, REST. |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/14 - Farmacologia |
| Depositato il: | 19 Apr 2021 11:39 |
| Ultima modifica: | 07 Giu 2023 10:36 |
| URI: | http://www.fedoa.unina.it/id/eprint/13842 |
Abstract
Since MeHg exposure hastens the onset of amyotrophic lateral sclerosis-like phenotype in SOD1G93A mice activating glutamate receptors and determined neuronal cell death by increasing REST expression, we invesigated the possible role of MeHg to accelerate reduction in cell survival in NSC-34 motor neuron like cells transiently transfected whit G93A-SOD1 construct via REST up regulation. Furthermore, we studied the trascriptional activators Sp1, Sp3, CREB and JunD. Additionally, we identified the epigenetic mechanism by which MeHg regulated REST gene. Since REST overexpression in neurons determined cell death by activating necroptosis, we investigated the role of MeHg to activate necroptosis in NSC34 cells overexpressing G93A-SOD1 construct
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