Serpico, Luigia (2021) New glycoconjugates with anti-oxidant activity for the development of supplements, useful in neurodegenerative diseases prevention. [Tesi di dottorato]


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Item Type: Tesi di dottorato
Resource language: English
Title: New glycoconjugates with anti-oxidant activity for the development of supplements, useful in neurodegenerative diseases prevention
Date: 14 July 2021
Number of Pages: 193
Institution: Università degli Studi di Napoli Federico II
Department: Scienze Chimiche
Dottorato: Scienze chimiche
Ciclo di dottorato: 33
Coordinatore del Corso di dottorato:
Pedatella, SilvanaUNSPECIFIED
Date: 14 July 2021
Number of Pages: 193
Keywords: Oxidative Stress, Deoxysugars, Selenium, Antioxidants, Neurodegenerative Diseases
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/06 - Chimica organica
Date Deposited: 22 Jul 2021 16:20
Last Modified: 07 Jun 2023 10:36

Collection description

Oxidative stress (OS) is a condition due to an imbalance between oxidants and antioxidants production. It occurs either when the former are prevalent, or the latter are reduced. If this alteration is prolonged in time, the physiological equilibrium is disrupted, leading to an oxidative damage in the involved tissues.1 It is now well established that OS is responsible for the initiation or development of many pathological processes, and may well become the salient feature to understand the pathogenesis of most of them.2 Indeed, oxidative stress has been associated with age related disorders,3,4 as well as cardiovascular diseases (CVDs),5,6 metabolic disorders7 like diabetes,8,9 cancer,10 neurodegenerative diseases11 (NDs) and many others. Moreover, OS can be considered an important therapeutic target to prevent oxidative states. In view of the foregoing, it is not surprising that the interest of scientific community has focused on preventive therapies for OS conditions, and inter alia, on those that involve the use of natural compounds as antioxidants. The latter - easily available in foods - can improve cellular defences helping the prevention of oxidative damage and have mostly no side effects for the body. Among natural antioxidants, polyphenols and selenium have been largely studied. In particular, organoselenium compounds have been described as potent antioxidants 12,13 and – among them- selenosugars work well as oxidant scavengers, being even better tolerated by the human body.14,15 Polyphenols, as well, own beneficial biological effects,16 including those related to their antioxidant properties.17 Nowadays, the large data available show that selenium and polyphenols' dietary assumption are recommended both to guarantee a redox balancing, and to counteract eventual oxidative stress conditions. Hence, the idea of the project: to synthetize a new set of molecules consisting of selenium containing monosaccharides bound to a phenolic moiety, which differ in the position of the bond. Furthermore, we investigated their potential antioxidant activity through chemical and cellular assays. Finally, taking into account the already documented beneficial effects of antioxidant treatment in wound healing,18,19 and the wide use of novel biocompatible hydrogels in wound dressing,20 we approached to the design and the development of a new device for transdermal delivery of antioxidants. In details, it consists of a high biocompatible thin polymeric hydrogel membrane containing the aforementioned synthesised organoselenium compounds.


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