Cerqua, Ida (2021) Development of new therapeutic strategies in the control of asthma. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Development of new therapeutic strategies in the control of asthma |
| Autori: | Autore Email Cerqua, Ida ida.cerqua@unina.it |
| Data: | 14 Aprile 2021 |
| Numero di pagine: | 172 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Farmacia |
| Dottorato: | Scienza del farmaco |
| Ciclo di dottorato: | 33 |
| Coordinatore del Corso di dottorato: | nome email D'Auria, Maria Valeria mariavaleria.dauria@unina.it |
| Tutor: | nome email Roviezzo, Fiorentina [non definito] |
| Data: | 14 Aprile 2021 |
| Numero di pagine: | 172 |
| Parole chiave: | airways; sex; hyperreactivity; |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/14 - Farmacologia |
| Depositato il: | 19 Apr 2021 07:53 |
| Ultima modifica: | 07 Giu 2023 11:07 |
| URI: | http://www.fedoa.unina.it/id/eprint/13869 |
Abstract
Asthma is a chronic inflammatory disease of the airways which affects more than 300 million people worldwide. Asthma treatment aims to improve patients' quality of life reducing airway inflammation and restoring respiratory function. Most patients can achieve good asthma control, but some patients do not. It seems increasingly evident that asthma is not a single and local disease but has different phenotypes and develops as a systemic disease, that could explain the non-constant therapeutic response. In light of this, the aim of this thesis project was to clarify on the one hand the involvement of sphingolipids such as sphingosine-1-phosphate (S1P) in the pathogenesis of asthma and on the other hand to clarify the contribution of sex hormones and vascular function to symptoms and exacerbations development. The results obtained demonstrate: • a key role SPK/S1P pathway in the development of bronchial hyperactivity as well as airway remodeling associated with exposure to cigarette smoke; • that sex hormones cause a sex dimorphism in bronchial hyperreactivity following allergen sensitization in favor of females. This sex dimorphism well correlate with leukotrienes upregulation in the lung; • that there is a strong and specific link between bronchial and vascular function and involvement of the pulmonary artery in determining the systemic impact of the disease. In conclusion, the data obtained confirm the complexity of asthmatic pathology and its relationship with other pulmonary and systemic inflammatory pathologies.
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