Criscuolo, Gjada (2021) Role of thymic stromal lymphopoietin (TSLP) in asthma. [Tesi di dottorato]


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Item Type: Tesi di dottorato
Resource language: English
Title: Role of thymic stromal lymphopoietin (TSLP) in asthma
Date: 8 April 2021
Number of Pages: 56
Institution: Università degli Studi di Napoli Federico II
Department: Scienze Mediche Traslazionali
Dottorato: Medicina clinica e sperimentale
Ciclo di dottorato: 33
Coordinatore del Corso di dottorato:
Date: 8 April 2021
Number of Pages: 56
Keywords: Asthma; TSLP; Cytokine.
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/05 - Patologia clinica
Area 06 - Scienze mediche > MED/09 - Medicina interna
Area 06 - Scienze mediche > MED/10 - Malattie dell'apparato respiratorio
Date Deposited: 20 Apr 2021 07:40
Last Modified: 07 Jun 2023 13:21

Collection description

Thymic Stromal Lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line and characterized as a lymphocyte growth factor. TSLP is predominantly expressed by lung and gut epithelial cells, keratinocytes, and by dendritic cells (DCs). TSLP can be produced also by airway smooth muscle (ASM) cells, mast cells, monocytes, macrophages and granulocytes, and cancer-associated fibroblasts (CAFs). There are two variants for TSLP in human tissues: the main isoform expressed in steady state is the short form (sfTSLP), which presumably plays a homeostatic role, whereas the long form (lfTSLP) is upregulated in inflammatory conditions. TSLP activates a specific heterodimeric receptor, identified on the majority of immune cells. The presence of TSLP receptor on a vast repertoire of cells indicates the relevance of this cytokine in various pathophysiological conditions. Indeed, TSLP has been implicated in several allergic diseases (e.g., bronchial asthma, atopic dermatitis, eosinophilic esophagitis), in chronic inflammatory (e.g., chronic obstructive pulmonary disease and celiac disease) and autoimmune (e.g., psoriasis, rheumatoid arthritis) disorders and in cancer. In this Ph.D. research project, we have investigated the role of TSLP in bronchial asthma. Our results suggest that circulating total TSLP is increased in patients with asthma compared to healthy controls. Plasma concentrations of total TSLP are not correlated to changes in forced expiratory volume in the 1st second (FEV1) and asthma control test (ACT) score in asthma patients. Collectively, these results indicate that TSLP could represent a promising relevant therapeutic target in asthma.


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