ILARDI, FEDERICA (2020) New echocardiographic and translational tools in valvular and ischemic heart disease. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | New echocardiographic and translational tools in valvular and ischemic heart disease |
| Autori: | Autore Email ILARDI, FEDERICA fedeilardi@gmail.com |
| Data: | 9 Dicembre 2020 |
| Numero di pagine: | 193 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Biomediche Avanzate |
| Dottorato: | Cardiovascular Pathophysiology and Therapeutics |
| Ciclo di dottorato: | 33 |
| Coordinatore del Corso di dottorato: | nome email Barbato, Emanuele emanuele.barbato@unina.it |
| Tutor: | nome email Esposito, Giovanni [non definito] |
| Data: | 9 Dicembre 2020 |
| Numero di pagine: | 193 |
| Parole chiave: | speckle-tracking echocardiography; myocardial work; multilayer strain; aortic stenosis; coronary artery disease; platelet aggregation. |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/11 - Malattie dell'apparato cardiovascolare |
| Depositato il: | 07 Gen 2021 11:13 |
| Ultima modifica: | 07 Giu 2023 10:20 |
| URI: | http://www.fedoa.unina.it/id/eprint/14094 |
Abstract
The advent of new methodologies applied to echocardiography, such as tissue Doppler imaging, 2D speckle tracking for myocardial deformation, and myocardial work assessment, has provided additional tools, capable of finer and earlier diagnosis of myocardial dysfunction. In addition, the ability to evaluate endothelial function and measure platelet aggregation has allowed to identify patients at increased risk for cardiovascular events and potential target of pharmacological treatment. In this research project we explored the role of these innovative and advanced tools, like strain parameters, myocardial work indices, and percentage of platelet aggregation, in the diagnosis of physiopathological mechanism underlying valvular and ischemic heart disease. Furthermore, we evaluated the prognostic value of speckle tracking echocardiography in aortic stenosis patients, from asymptomatic status to transcatheter aortic valve implantation, and its accuracy in the prediction of coronary artery disease. Finally, we investigated how factors such as hyperglycemia, hypercholesterolemia and uremia affect endothelial and platelet function, detecting new compounds able to counteract their pathological effects. To date, most of these investigated methodologies are mainly used for research purpose; further and larger studies are needed to definitely attest their adding value, in order to include their use in the routine clinical practice.
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