Scotto, Riccardo (2021) Risk factors for respiratory function deterioration in patients hospitalised for COVID-19: The ASCL (Age, Sex, CRP, LDH) score. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Risk factors for respiratory function deterioration in patients hospitalised for COVID-19: The ASCL (Age, Sex, CRP, LDH) score |
| Autori: | Autore Email Scotto, Riccardo riccardo.scotto@unina.it |
| Data: | 8 Dicembre 2021 |
| Numero di pagine: | 89 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Medicina Clinica e Chirurgia |
| Dottorato: | Terapie avanzate biomediche e chirurgiche |
| Ciclo di dottorato: | 34 |
| Coordinatore del Corso di dottorato: | nome email Di Minno, Giovanni giovanni.diminno@unina.it |
| Tutor: | nome email Gentile, Ivan [non definito] |
| Data: | 8 Dicembre 2021 |
| Numero di pagine: | 89 |
| Parole chiave: | COVID-19, SARS-CoV-2, risk factors, prognostic score, |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/05 - Patologia clinica Area 06 - Scienze mediche > MED/10 - Malattie dell'apparato respiratorio Area 06 - Scienze mediche > MED/17 - Malattie infettive |
| Depositato il: | 22 Dic 2021 08:07 |
| Ultima modifica: | 28 Feb 2024 11:37 |
| URI: | http://www.fedoa.unina.it/id/eprint/14328 |
Abstract
The pandemic of coronavirus disease 2019 has caused an unprecedent global social and economic impact, and high numbers of deaths. A good understanding of the possible risk factors is helpful for clinicians in identifying patients who are at high risk and require prioritised treatment to prevent disease progression and adverse outcome. In this retrospective multicenter study including patients hospitalised for COVID-19, the prognostic role of CRP and LDH at admission in predicting deterioration of respiratory function was evaluated. The results showed that both CRP and LDH at admission are associated with respiratory function deterioration during hospitalisation. Moreover a score composed of Age, Sex, CRP and LDH was also associated with significant respiratory deterioration. These parameters should be taken into account to choose patients to be prioritised for careful respiratory function monitoring and early treatment with specific drugs, in order to prevent a progression of the disease.
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