Muto, Massimo (2021) Evaluation of the safety, efficacy and histological changes of a new mixture of Glubran®2 + Ethanol + Lipiodol ® (G.E.L.) as embolic agent in neurovascular procedures – animal lab experience. [Tesi di dottorato]
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MUTO_34.pdf Download (15MB) | Anteprima |
| Tipologia del documento: | Tesi di dottorato | ||||
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| Lingua: | English | ||||
| Titolo: | Evaluation of the safety, efficacy and histological changes of a new mixture of Glubran®2 + Ethanol + Lipiodol ® (G.E.L.) as embolic agent in neurovascular procedures – animal lab experience | ||||
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| Data: | Dicembre 2021 | ||||
| Numero di pagine: | 54 | ||||
| Istituzione: | Università degli Studi di Napoli Federico II | ||||
| Dipartimento: | Neuroscienze e Scienze Riproduttive ed Odontostomatologiche | ||||
| Dottorato: | Neuroscienze | ||||
| Ciclo di dottorato: | 34 | ||||
| Coordinatore del Corso di dottorato: |
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| Data: | Dicembre 2021 | ||||
| Numero di pagine: | 54 | ||||
| Parole chiave: | Angionecrosis, arteriovenous malformation, endovascular embolization, experimentally induced aneurysm, N-butyl cyanoacrylate | ||||
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/26 - Neurologia Area 06 - Scienze mediche > MED/27 - Neurochirurgia Area 06 - Scienze mediche > MED/36 - Diagnostica per immagini e radioterapia Area 06 - Scienze mediche > MED/37 - Neuroradiologia |
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| Depositato il: | 17 Dic 2021 08:18 | ||||
| Ultima modifica: | 28 Feb 2024 11:33 | ||||
| URI: | http://www.fedoa.unina.it/id/eprint/14339 |
Abstract
Purpose: The aim of this study was to investigate the degree of penetration, permanence of occlusion and vascular changes induced by a modified mixture of n-butyl cyanoacrylate (Glubran 2®), ethanol and Lipidol® (G.E.L.) in endovascular treatment of experimental aneurysms induced in swine. Methods: Bilateral pouch aneurysms were created in the wall of the internal carotid artery in eight pigs. The sixteen aneurysms were treated with a mixture of G.E.L. in different dilution between components. Angiograms were obtained at the time of treatment and at 1, 4, and 16 weeks after treatment. According to the schedule experimental design, subjects were sacrificed at the time of treatment and 7-, 30-, and 90-days after embolization of experimentally induced aneurysms. The internal carotid artery and aneurysms were resected en bloc and fixed for histopathologic study. Results: All the experimentally induced aneurysm were completely occluded by the used mixture and remained occluded for the study period without recanalization. Histopathologic studies revealed the presence of an acute inflammatory reaction of aneurysm wall even after 7 days post embolization with focal angionecrosis, followed by a chronic inflammation which induced a thickening of the wall. No inflammatory changes were observed in the host tissues at the periphery of the experimentally induced lesion. Conclusions: The mixture used for embolization of aneurysms succeeded to induce a complete occlusion which remained stable until 90 days post-embolization. After seven days from embolization, the mixture polymerization was associated with an acute inflammatory response followed by a connective tissue proliferation which induced a thickening of aneurysm walls, without involvement of host tissue at the periphery of experimentally induced lesions.
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