Sciarretta, Martina (2022) Rational design and sustainable synthesis of combinatorial libraries of heterocyclic scaffolds with potential therapeutic effects. [Tesi di dottorato]

	Testo Sciarretta_Martina_COMPLETO.pdf Visibile a [TBR] Amministratori dell'archivio Download (5MB) | Richiedi una copia
Anteprima	Testo Sciarretta_Martina_PARZIALE.pdf Download (5MB) | Anteprima

Abstract

A rational design and synthesis of small heterocyclic molecules as potential modulators of emerging targets with therapeutical effects is here presented. This research was addressed to the investigation of anti-inflammatory, anticancer and antibiotic activity. A multistep computational approach was carried out for the generation of an extensive library of 1,2,4-oxadiazoles of compounds to select the best virtual candidates for the development of new potential agents interfering with several pathways. The synthetic phase of a multidisciplinary workflow was focused on the identification of novel promising chemical entities. Biological assays on small molecules were performed to confirm the predicted activity towards the targets. Moreover, with the main purpose to develop an efficient and sustainable synthetic approach capable to generate heterocyclic compounds, a small library of 1,3,4-oxadiazoles was obtained using an innovative nanohybrid material as heterogeneous photocatalyst.

Downloads

Actions (login required)

Modifica documento