Sciarretta, Martina (2022) Rational design and sustainable synthesis of combinatorial libraries of heterocyclic scaffolds with potential therapeutic effects. [Tesi di dottorato]

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Item Type: Tesi di dottorato
Resource language: English
Title: Rational design and sustainable synthesis of combinatorial libraries of heterocyclic scaffolds with potential therapeutic effects
Creators:
CreatorsEmail
Sciarretta, Martinamartina.sciarretta@unina.it
Date: April 2022
Number of Pages: 183
Institution: Università degli Studi di Napoli Federico II
Department: Farmacia
Dottorato: Scienza del farmaco
Ciclo di dottorato: 34
Coordinatore del Corso di dottorato:
nomeemail
D'Auria, Maria Valeriamadauria@unina.it
Tutor:
nomeemail
D'Auria, Maria ValeriaUNSPECIFIED
Date: April 2022
Number of Pages: 183
Keywords: oxadiazoles, bioactive molecules, photocatalysis
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/06 - Chimica organica
Date Deposited: 16 Mar 2022 15:52
Last Modified: 28 Feb 2024 11:02
URI: http://www.fedoa.unina.it/id/eprint/14402

Collection description

A rational design and synthesis of small heterocyclic molecules as potential modulators of emerging targets with therapeutical effects is here presented. This research was addressed to the investigation of anti-inflammatory, anticancer and antibiotic activity. A multistep computational approach was carried out for the generation of an extensive library of 1,2,4-oxadiazoles of compounds to select the best virtual candidates for the development of new potential agents interfering with several pathways. The synthetic phase of a multidisciplinary workflow was focused on the identification of novel promising chemical entities. Biological assays on small molecules were performed to confirm the predicted activity towards the targets. Moreover, with the main purpose to develop an efficient and sustainable synthetic approach capable to generate heterocyclic compounds, a small library of 1,3,4-oxadiazoles was obtained using an innovative nanohybrid material as heterogeneous photocatalyst.

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