Mancusi, Costantino (2022) Myocardial energetic efficiency, a new tool for cardiovascular risk assestement. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Myocardial energetic efficiency, a new tool for cardiovascular risk assestement |
| Autori: | Autore Email Mancusi, Costantino costantino.mancusi@unina.it |
| Data: | 11 Marzo 2022 |
| Numero di pagine: | 42 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Biomediche Avanzate |
| Dottorato: | Medicina clinica e sperimentale |
| Ciclo di dottorato: | 34 |
| Coordinatore del Corso di dottorato: | nome email Beguinot, Francesco beguino@unina.it |
| Tutor: | nome email de Simone, Giovanni [non definito] |
| Data: | 11 Marzo 2022 |
| Numero di pagine: | 42 |
| Parole chiave: | Cardiovascular risk, Prognosis, Myocardial performance |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/09 - Medicina interna |
| Depositato il: | 21 Mar 2022 11:05 |
| Ultima modifica: | 28 Feb 2024 11:00 |
| URI: | http://www.fedoa.unina.it/id/eprint/14421 |
Abstract
Cardiac mechanical energetic efficiency is the ratio of external work (EW) to the total energy consumption. EW performed by the left ventricle (LV) during a single beat is represented by LV stroke work and may be calculated from the pressure-volume loop area (PVLA), while energy consumption corresponds to myocardial oxygen consumption (MVO2) expressed on a per-beat basis. Classical early human studies estimated total mechanical LV efficiency at 20-30%, whereas the remaining energy is dissipated as heat. As practical assessment of LV efficiency poses methodological problems, de Simone et al. proposed a simple surrogate measure of myocardial efficiency, i.e., mechano-energetic efficiency index (MEEi) calculated from LV stroke volume, heart rate and LV mass. In two independent cohorts, including a large group of hypertensive subjects and a population-based cohort (both free of prevalent cardiovascular disease and with preserved ejection fraction), low MEEi independently predicted composite incident adverse cardiovascular events and, specifically, heart failure. The aim of the present thesis is to demonstrate the prognostic ability of low MEEi in different clinical condition and assess its utility as novel noninvasive diagnostic tool.
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