Gallicchio, Vito (2022) DESIGN STRATEGIES TOWARDS THE DEVELOPMENT OF ADVANCED SYSTEMS AND DEVICES IN CLINICAL AND EXPERIMENTAL MEDICINE. [Tesi di dottorato]

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Abstract

In the current PhD thesis different topics related to the dentistry field have been studied and analyzed. First, the focus has been devoted to the design of advanced devices for bone tissue regeneration during the orthodontic movement. In this area there is a particular attention to reduce the orthodontic treatment time by speeding up the tooth movement since, generally, the aforementioned treatment takes an average time of 18-24 months. A promising approach may be given by the coupling of static magnetic fields (SMFs) and non-ionizing electromagnetic fields (EMFs) with advanced devices in the form of “solid” 3D additive manufactured magnetic scaffolds and/or injectable gels to improve cell activity by enhancing cell signaling and guiding cell migration, proliferation and differentiation. This approach would be possible thanks to the use of magnetic nanoparticles (e.g., Fe3O4) that show a superparamagnetic behavior. Different studies have also been carried out in the conservative dentistry field by engineering technical solutions as well as by testing and analyzing polymers, composites and biological tissues, in terms of mechanical properties, thermal properties and surface/interface adhesion. These studies would be useful to define new clinical procedures and to analyze the long-term effects of dental materials, endodontic fiber-reinforced posts and reconstruction techniques on the success of dental restorations.

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