Marcella, Simone (2022) Vascular Endothelial Growth Factors and Angiopoietins as New Players in Mastocytosis. [Tesi di dottorato]


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Item Type: Tesi di dottorato
Resource language: English
Title: Vascular Endothelial Growth Factors and Angiopoietins as New Players in Mastocytosis
Date: 2 March 2022
Number of Pages: 46
Institution: Università degli Studi di Napoli Federico II
Department: Scienze Mediche Traslazionali
Dottorato: Medicina clinica e sperimentale
Ciclo di dottorato: 34
Coordinatore del Corso di dottorato:
Loffredo, StefaniaUNSPECIFIED
Date: 2 March 2022
Number of Pages: 46
Keywords: angiopoietins; ANGPT; mast cells; mastocytosis; stem cell factor; tryptase; vascular endothelial growth factors; VEGF-A; VEGF-C
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/05 - Patologia clinica
Area 06 - Scienze mediche > MED/09 - Medicina interna
Date Deposited: 17 Mar 2022 08:41
Last Modified: 28 Feb 2024 14:16

Collection description

Background: Mastocytosis is a disorder characterized by the abnormal proliferation and/or accumulation of mast cells in different organs. More than 90% of patients with systemic mastocytosis have a gain-of-function mutation in codon 816 of the KIT receptor on mast cells (MCs). The symptoms of mastocytosis patients are related to the MC-derived mediators that exert local and distant effects. MCs produce angiogenic and lymphangiogenic factors, including vascular endothelial growth factors (VEGFs) and angiopoietins (ANGPTs). Methods: Serum concentrations of VEGF-A, VEGF-C, VEGF-D, ANGPT1 and ANGPT2 were determined in 64 mastocytosis patients and 64 healthy controls. Intracellular concentrations and spontaneous release of these mediators were evaluated in the mast cell lines ROSAKIT WT and ROSAKIT D816V . Results: VEGF-A, ANGPT1, ANGPT2 and VEGF-C concentrations were higher in mastocytosis patients compared to controls. The VEGF-A, ANGPT2 and VEGF-C concentrations were correlated with the symptom severity. ANGPT1 concentrations were increased in all patients compared to controls. ANGPT2 levels were correlated with severity of clinical variants and with tryptase levels. VEGF-A, ANGPT1 and VEGF-C did not differ between indolent and advanced mastocytosis. ROSAKIT WT and ROSAKIT D816V contained and spontaneously released VEGFs and ANGPTs. Conclusion: Serum concentrations of VEGFs and ANGPTs are altered in mastocytosis patients.


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