Marzano, Federica (2022) Novel Roles of GRK2 and GRK5 in Cardiovascular Diseases. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Novel Roles of GRK2 and GRK5 in Cardiovascular Diseases |
| Autori: | Autore Email Marzano, Federica federica.marzano@outlook.com |
| Data: | 10 Gennaio 2022 |
| Numero di pagine: | 73 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Biomediche Avanzate |
| Dottorato: | Cardiovascular Pathophysiology and Therapeutics |
| Ciclo di dottorato: | 34 |
| Coordinatore del Corso di dottorato: | nome email Izzo, Raffaele rafizzo@unina.it |
| Tutor: | nome email Rapacciuolo, Antonio [non definito] |
| Data: | 10 Gennaio 2022 |
| Numero di pagine: | 73 |
| Parole chiave: | Heart Failure; GRK2; GRK5 |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/11 - Malattie dell'apparato cardiovascolare |
| Depositato il: | 29 Dic 2021 08:25 |
| Ultima modifica: | 28 Feb 2024 14:21 |
| URI: | http://www.fedoa.unina.it/id/eprint/14617 |
Abstract
Heart failure (HF) is one of the leading causes of morbidity and mortality worldwide, with a heavy burden on global healthcare systems. Molecularly, HF is characterized by the upregulation of G protein-coupled receptor (GPCR) kinases (GRKs). These kinases regulate GPCR signaling via phosphorylation and subsequent desensitization of activated receptors. Among GRKs, GRK2 and GRK5, are the major isoforms expressed in the heart, and the levels of these kinases are elevated in human failing myocardium. Significant progress has been made in understanding the pathological role of these kinases in the heart, both as GPCR kinases and as molecules that can act independently of GPCRs, in a “non-canonical” manner. This thesis is a collection of several research studies, aiming at elucidating the role of GRKs in the modulation of cellular processes, thus providing novel insight into molecular mechanisms underlying cardiac dysfunction.
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