Di Stasi, Martina (2022) The role of UBOs in the neurocognitive profile of neurofibromatosis type 1 children: a volumetric MRI analysis. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | The role of UBOs in the neurocognitive profile of neurofibromatosis type 1 children: a volumetric MRI analysis |
| Autori: | Autore Email Di Stasi, Martina martinadistasi@live.it |
| Data: | 10 Dicembre 2022 |
| Numero di pagine: | 18 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Biomediche Avanzate |
| Dottorato: | Scienze biomorfologiche e chirurgiche |
| Ciclo di dottorato: | 35 |
| Coordinatore del Corso di dottorato: | nome email Cuocolo, Alberto [non definito] |
| Tutor: | nome email Elefante, Andrea [non definito] |
| Data: | 10 Dicembre 2022 |
| Numero di pagine: | 18 |
| Parole chiave: | Neurofibromatosis; UBOs; MRI |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/37 - Neuroradiologia Area 06 - Scienze mediche > MED/38 - Pediatria generale e specialistica |
| Depositato il: | 16 Dic 2022 18:24 |
| Ultima modifica: | 09 Apr 2025 14:10 |
| URI: | http://www.fedoa.unina.it/id/eprint/14683 |
Abstract
Introduction: Cognitive impairment is described in 80% of NF1 children, with a general lowering of one standard deviation in IQ scores, and language disabilities found in about 50% of cases. Given their prevalence, UBOs have been hypothesized to be related with cognitive dysfunction and extensively indagated in literature, with conflicting results. Given this background, we tried to investigate the relation between UBOs’ volume, cognitive and language impairment. Materials and Methods: We retrospectively recruited 21 NF1 children: intellectual functioning and language abilities were assessed with WISC IV. MRI data were acquired on the same scanner. Axial TSE T2-weighted and FLAIR images were used for the UBOs segmentation. The presence and extent of OPG were evaluated. UBOs volumes’ differences between cognitively affected and preserved patients, and between subjects with or without language impairment were tested via General Linear Model analyses. As previous data suggested an association between OPG and UBOs, we investigated if a similar feature was present in our group. Volume disparities evaluated on FLAIR or T2-weighted images were verified via paired t test. RESULTS: We found a significantly higher lesional volumes when segmentation was obtained on FLAIR images. When probing possible differences between cognitively affected and preserved patients, we failed to find significant differences. No differences occurred between patients with or without language impairment and with and without OPG. Given the available literature, we hypothesized that cognitive impairment and language deficit might be related to pervasive abnormal connectivity and corroborated the hypothesis that UBOs don’t play a significant role in determining the neurocognitive profile
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