Greco, Francesca (2022) DNA AND RNA OLIGONUCLEOTIDES IN THERAPY: THE PROMISING APPLICATIONS. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | DNA AND RNA OLIGONUCLEOTIDES IN THERAPY: THE PROMISING APPLICATIONS |
| Autori: | Autore Email Greco, Francesca francesca.greco@unina.it |
| Data: | 9 Dicembre 2022 |
| Numero di pagine: | 157 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Biologia |
| Dottorato: | Biotecnologie |
| Ciclo di dottorato: | 35 |
| Coordinatore del Corso di dottorato: | nome email Moracci, Marco marco.moracci@unina.it |
| Tutor: | nome email Piccialli, Gennaro [non definito] |
| Data: | 9 Dicembre 2022 |
| Numero di pagine: | 157 |
| Parole chiave: | oligonucleotide; DNA; RNA; PNA |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/06 - Chimica organica |
| Depositato il: | 22 Dic 2022 11:01 |
| Ultima modifica: | 09 Apr 2025 14:08 |
| URI: | http://www.fedoa.unina.it/id/eprint/14689 |
Abstract
Oligonucleotides are small molecules with easy-to-handle design and rapid production steps that have already proven their extraordinary efficacy, as witnessed by the recent development of mRNA-based vaccines against the SARS-CoV-2 virus. Natural oligonucleotides are not suitable for therapy and diagnostics due to their low thermal and enzymatic stability and modest bioavailability. Still synthetic oligonucleotide (ODN) analogous are synthesized for increasing their application. In this contest, my research studied the (ODN) relevance in diagnostics and therapy. Specifically, my research work has been focused on: o Chemical synthesis and structural and biological characterization of Peptide Nucleic Acids (PNAs) as antisense oligonucleotide and development of novel delivery platforms o Stabilization of the c-myc promoter region conformed in G-quadruplexes as promising antitumoral approach. o Realization of a new supramolecular structures formed by C-rich oligonucleotides (CROs) sequences through the introduction of non-nucleotidic linker.
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