D'Alessio, Federica (2023) Engineering the HEK293 packaging cell line to improve simian Adenoviral vaccine production. [Tesi di dottorato]
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| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | Engineering the HEK293 packaging cell line to improve simian Adenoviral vaccine production |
| Creators: | Creators Email D'Alessio, Federica federica.dalessio@unina.it |
| Date: | 10 March 2023 |
| Number of Pages: | 52 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Medicina Molecolare e Biotecnologie Mediche |
| Dottorato: | Medicina molecolare e biotecnologie mediche |
| Ciclo di dottorato: | 35 |
| Coordinatore del Corso di dottorato: | nome email Santoro, Massimo masantor@unina.it |
| Tutor: | nome email Mallardo, Massimo UNSPECIFIED |
| Date: | 10 March 2023 |
| Number of Pages: | 52 |
| Keywords: | Adenovirus;vaccine;HEK293 packaging cell line;genetic engineering |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/13 - Biologia applicata |
| Date Deposited: | 21 Mar 2023 10:38 |
| Last Modified: | 10 Apr 2025 12:39 |
| URI: | http://www.fedoa.unina.it/id/eprint/15046 |
Collection description
This study employed several approaches to expedite and improve non-human Adenoviral vector-based vaccine production process in the HEK293 packaging cell line. Engineered HEK293 packaging cell line enables the acceleration and the optimization of simian-derived Adenoviral vaccine production as well as the improvement of viral preparation quality for large-scale vaccine production.
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