Migliaccio, Teresa (2023) Glucose promotes breast cancer cell stemness and invasiveness by modulating the interaction with mammary adipose tissue-derived mesenchymal stem cells. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Glucose promotes breast cancer cell stemness and invasiveness by modulating the interaction with mammary adipose tissue-derived mesenchymal stem cells |
| Autori: | Autore Email Migliaccio, Teresa teresa.migliaccio89@gmail.com |
| Data: | 8 Marzo 2023 |
| Numero di pagine: | 67 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Scienze Mediche Traslazionali |
| Dottorato: | Medicina clinica e sperimentale |
| Ciclo di dottorato: | 35 |
| Coordinatore del Corso di dottorato: | nome email Beguinot, Francesco beguino@unina.it |
| Tutor: | nome email Formisano, Pietro [non definito] |
| Data: | 8 Marzo 2023 |
| Numero di pagine: | 67 |
| Parole chiave: | Glucosio, interazione tumore-stroma |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/05 - Patologia clinica |
| Depositato il: | 22 Mar 2023 07:32 |
| Ultima modifica: | 10 Apr 2025 14:06 |
| URI: | http://www.fedoa.unina.it/id/eprint/15174 |
Abstract
Epidemiological studies report that patients with type 2 diabetes (T2D) show an increased risk of developing several types of cancer, including breast cancer (100). Associations between T2D and breast cancer have been intensively studied, particularly regarding diabetes and the risk and prognosis of breast cancer (16). Diabetes is associated with a 14% to 25% increased risk of breast cancer, with a 37% to 61% elevated hazard of all-cause mortality in breast cancer patients. (101). The tumor microenvironment plays an important role in neoplastic development (51). Adipose tissue represents an important component of the tumor microenvironment, especially in breast cancer and actively intervenes in the association between diabetes and cancer (54). Hyperglycemia represents the main metabolic alteration that characterizes T2D and is associated with a more aggressive cancerous phenotype in breast cancer patients. Mammary Adipose tissue (MAT) responds to metabolic, inflammatory and tumoral stimuli by releasing various molecules to sustain breast cancer cells proliferation, migration, invasiveness and drug resistance (57,58,59). MAT is rich in Mesenchymal Stem Cells (MSCs), which may support tumour phenotype by either acting as energy reservoirs for cancer cells or through the secretion of signaling molecules (66). In turn, cancer cells, following metabolic alterations like hyperglycemia, may modify the surrounding-MSCs phenotype for their own advantage. Thus, MSCs and cancer cells establish a dangerous duo. In this scenario, diabetes-associated hyperglycemia may affect on both cancer and surrounding stromal cells, including MSCs. Thus, this PhD work aims to investigate the impact of glucose on the bi-directional communication between breast cancer cells and mesenchymal stem cells and the effect of glucose-modulated MSCs onto MCF7 breast cancer cells progression and aggressiveness.
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