Nazzaro, Martina (2023) Sugar and brain disfunction:persistence of molecular alterations induced by a high-fructose diet in a juvenile rodent model. [Tesi di dottorato]

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Abstract

Young age is often characterized by high consumption of processed foods, sodas, and fruit juices rich in high-fuctose corn syrup (HFCS), which is corn syrup. In recent years it has emerged that this compound, widely used in industry as a sweetener, induces not onlyoverweight, dyslipidemia, liver damage and metabolic syndrome in general, but can also cause alterations in brain function. The objectives of this PhD project were to (a) clarify the cerebral effects deriving from the consumption of fructose at a young age, a critical phase for brain development, and (b) study whether the cerebral alterations induced by an excess of sugars are abolished or persist after the elimination of the sugar and the switch to a balanced diet. The study was conducted both on the hippocampus and frontal cortex, two areas of the brain involved in learning and memory, particularly susceptible to nutritional insults, and on the hypothalamus, an important district for the regulation of energy balance.

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