Crocetto, Felice Erectile dysfunction and obstructive sleep apnoea: a cross-sectional clinical study. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Erectile dysfunction and obstructive sleep apnoea: a cross-sectional clinical study |
| Autori: | Autore Email Crocetto, Felice felice.crocetto@unina.it |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Neuroscienze e Scienze Riproduttive ed Odontostomatologichei |
| Dottorato: | Neuroscienze |
| Ciclo di dottorato: | 35 |
| Coordinatore del Corso di dottorato: | nome email Taglialatela, Maurizio [non definito] |
| Tutor: | nome email Imbimbo, Ciro [non definito] |
| Parole chiave: | Erectile Dysfunction (ED), Obstructive sleep apnoea (OSA), ED etiopathogenesis; Aging; Diabetes mellitus; Hypertension; SatO2; Sex-hormones; ED management; ED treatment. |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/24 - Urologia |
| Depositato il: | 16 Dic 2022 12:13 |
| Ultima modifica: | 10 Apr 2025 14:22 |
| URI: | http://www.fedoa.unina.it/id/eprint/15240 |
Abstract
State of the art: Erectile Dysfunction (ED) is the inability to achieve or maintain an erection for satisfactory sexual performance. Recently, it has been suggested that obstruct�tive sleep apnoea (OSA) can induce ED. Sleep fragmentation and sympathetic hyper�activity after OSA that induce reduced nocturnal erections in the rapid eye movement (REM) periods and hormonal status modifications, as well as comorbidities observed in both diseases could be involved in the ED pathogenesis. Purpose: In this study the impact of nonendocrine (neurogenic, vasculogenic and iatro�genic) and endocrine pathways involved in ED pathogenesis have been analyzed. In particular, a cross-sectional study has been performed to investigate the prevalence and clinical characteristics of ED in patients with OSA. Methods: We enrolled 133 male patients with suspected OSA. Ear, nose and throat eva�luation, laboratory tests, body mass index, Epworth sleepiness scale, 5-international index of erectile function, overnight ambulatory polygraphy and drug-induced sleep endoscopy patterns were assessed. Eighty patients reported OSA. 60% (n = 48) reported ED. Results: Statistically significant correlations were found between 5-International Index of Erectile Function and age, hypertension, diabetes, Epworth sleepiness scale, apnoea-hypo�pnea index score, O2 saturation-nadir, and oxygen desaturation index. Age, diabetes and O2 saturation-nadir were independent predictors of ED. Epworth sleepiness scale, apnoea�hypopnea index score, O2 saturation-nadir, oxygen desaturation index and albumin were higher compared to patients without ED. No statistically significant differences were reported for drug-induced sleep endoscopy patterns and ED. Conclusions: This study confirmed that OSA is a risk factor for ED. In particular, our data demonstrated that OSA parameters correlate with ED and age, while SatO2-nadir and diabetes are independent predictors of ED. Our research pointed out that men presenting to the Ear, nose and throat (ENT) clinic with OSA are at significant risk of having ED. There�fore, males with OSA should be investigated for ED.
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