De Conno, Barbara (2024) The Effects of a Cinchona Supplementation on Satiety, Weight Loss and Body Composition in a Population of Overweight/Obese Adults: A Controlled Randomized Study. [Tesi di dottorato]
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | The Effects of a Cinchona Supplementation on Satiety, Weight Loss and Body Composition in a Population of Overweight/Obese Adults: A Controlled Randomized Study |
| Autori: | Autore Email De Conno, Barbara barbara.deconno@gmail.com |
| Data: | 2 Marzo 2024 |
| Numero di pagine: | 42 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Farmacia |
| Dottorato: | Nutraceuticals, Functional Foods and Human Healt |
| Ciclo di dottorato: | 36 |
| Coordinatore del Corso di dottorato: | nome email Izzo, Angelo aaizzo@unina.it |
| Tutor: | nome email Miniaci, Maria Concetta [non definito] |
| Data: | 2 Marzo 2024 |
| Numero di pagine: | 42 |
| Parole chiave: | Obesity; cinchona; nutraceutical treatment; body composition analysis; gut hormone; bitter tast. |
| Settori scientifico-disciplinari del MIUR: | Area 05 - Scienze biologiche > BIO/09 - Fisiologia Area 05 - Scienze biologiche > BIO/10 - Biochimica Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare Area 05 - Scienze biologiche > BIO/14 - Farmacologia |
| Depositato il: | 21 Mar 2024 10:20 |
| Ultima modifica: | 14 Apr 2026 07:13 |
| URI: | http://www.fedoa.unina.it/id/eprint/15570 |
Abstract
Obesity is a risk factor for several diseases present worldwide. Currently, dietary changes and physical activity are considered the most effective treatment to reduce obesity and its associated comorbidities. To promote weight loss, hypocaloric diets can be supported by nutraceuticals. The aim of this study was to evaluate the effects of a hypocaloric diet associated with cinchona succirubra supplementation on satiety, body weight and body composition in obese subjects. Fifty-nine overweight/obese adults were recruited, randomized into two groups and treated for 2 months. The first group (32 adults) was treated with a hypocaloric diet plus cinchona supplementation (the T-group); the second one (27 adults) was treated with a hypocaloric diet plus a placebo supplementation (the P-group). Anthropometric measurements as well as bioimpedance analysis, a Zung test and biochemical parameters were evaluated at baseline and after 60 days. T-group adults showed significant improvement in nutritional status and body composition compared to those at the baseline and in the P-group. Moreover, T-group adults did not show a reduction in Cholecystokinin serum levels compared to those of P-group adults. In conclusion, our data demonstrate that a hypocaloric diet associated with cinchona supplementation is effective in inducing more significant weight loss and the re-establishment of metabolic parameters than those obtained with a hypocaloric diet.
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