Lavorgna, Alfonso
(2008)
Regulation of the NF-kappaB alternative pathway: implication for B cell transformation.
[Tesi di dottorato]
(Unpublished)
| Item Type: |
Tesi di dottorato
|
| Lingua: |
English |
| Title: |
Regulation of the NF-kappaB alternative pathway: implication for B cell transformation |
| Creators: |
| Creators | Email |
|---|
| Lavorgna, Alfonso | alfonso.lavorgna@libero.it |
|
| Date: |
9 December 2008 |
| Number of Pages: |
46 |
| Institution: |
Università degli Studi di Napoli Federico II |
| Department: |
Biologia e patologia cellullare e molecolare "L. Califano" |
| Scuola di dottorato: |
Medicina molecolare |
| Dottorato: |
Oncologia ed endocrinologia molecolare |
| Ciclo di dottorato: |
21 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| Vecchio, Giancarlo | vecchio@unina.it |
|
| Tutor: |
| nome | email |
|---|
| Leonardi, Antonio | leonardi@unina.it |
|
| Date: |
9 December 2008 |
| Number of Pages: |
46 |
| Uncontrolled Keywords: |
NF-kappaB, TRAF1, BAFF Receptor |
| Settori scientifico-disciplinari del MIUR: |
Area 06 - Scienze mediche > MED/04 - Patologia generale |
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| Date Deposited: |
06 Jul 2010 10:59 |
| Last Modified: |
30 Apr 2014 19:39 |
| URI: |
http://www.fedoa.unina.it/id/eprint/4003 |
| DOI: |
10.6092/UNINA/FEDOA/4003 |
Abstract
The NF-B2 gene is recurrently mutated and over-expressed in human lymphoid malignancies. However, a casual relationship between NF-B2 mutation and lymphomagenesis has not been established. It is also unclear how the mutation may lead to lymphoid malignancies. Recent studies suggest that nuclear factor B inducing kinase (NIK) is suppressed through constitutive proteasome-mediated degradation regulated by TRAF3, thus preventing processing of the NF-B2 precursor protein p100 to release p52. Here we demonstrate that BAFF Receptor, a member of the TNF Receptor family, interact with TRAF1, a member of TRAF family. This interaction activates NF-B2 via increased degradation of TRAF3 and stabilization of NIK. Indeed, interference of TRAF1 in lymphoma B cell line downregulates p100 processing and lead to decreased survival of B cells.
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