Lavorgna, Alfonso (2008) Regulation of the NF-kappaB alternative pathway: implication for B cell transformation. [Tesi di dottorato] (Inedito)

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Tipologia del documento: Tesi di dottorato
Lingua: English
Titolo: Regulation of the NF-kappaB alternative pathway: implication for B cell transformation
Autori:
AutoreEmail
Lavorgna, Alfonsoalfonso.lavorgna@libero.it
Data: 9 Dicembre 2008
Numero di pagine: 46
Istituzione: Università degli Studi di Napoli Federico II
Dipartimento: Biologia e patologia cellullare e molecolare "L. Califano"
Scuola di dottorato: Medicina molecolare
Dottorato: Oncologia ed endocrinologia molecolare
Ciclo di dottorato: 21
Coordinatore del Corso di dottorato:
nomeemail
Vecchio, Giancarlovecchio@unina.it
Tutor:
nomeemail
Leonardi, Antonioleonardi@unina.it
Data: 9 Dicembre 2008
Numero di pagine: 46
Parole chiave: NF-kappaB, TRAF1, BAFF Receptor
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/04 - Patologia generale
Depositato il: 06 Lug 2010 10:59
Ultima modifica: 30 Apr 2014 19:39
URI: http://www.fedoa.unina.it/id/eprint/4003
DOI: 10.6092/UNINA/FEDOA/4003

Abstract

The NF-B2 gene is recurrently mutated and over-expressed in human lymphoid malignancies. However, a casual relationship between NF-B2 mutation and lymphomagenesis has not been established. It is also unclear how the mutation may lead to lymphoid malignancies. Recent studies suggest that nuclear factor B inducing kinase (NIK) is suppressed through constitutive proteasome-mediated degradation regulated by TRAF3, thus preventing processing of the NF-B2 precursor protein p100 to release p52. Here we demonstrate that BAFF Receptor, a member of the TNF Receptor family, interact with TRAF1, a member of TRAF family. This interaction activates NF-B2 via increased degradation of TRAF3 and stabilization of NIK. Indeed, interference of TRAF1 in lymphoma B cell line downregulates p100 processing and lead to decreased survival of B cells.

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