Lavorgna, Alfonso (2008) Regulation of the NF-kappaB alternative pathway: implication for B cell transformation. [Tesi di dottorato] (Unpublished)


Download (3MB) | Preview
[error in script] [error in script]
Item Type: Tesi di dottorato
Lingua: English
Title: Regulation of the NF-kappaB alternative pathway: implication for B cell transformation
Date: 9 December 2008
Number of Pages: 46
Institution: Università degli Studi di Napoli Federico II
Department: Biologia e patologia cellullare e molecolare "L. Califano"
Scuola di dottorato: Medicina molecolare
Dottorato: Oncologia ed endocrinologia molecolare
Ciclo di dottorato: 21
Coordinatore del Corso di dottorato:
Date: 9 December 2008
Number of Pages: 46
Uncontrolled Keywords: NF-kappaB, TRAF1, BAFF Receptor
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/04 - Patologia generale
Date Deposited: 06 Jul 2010 10:59
Last Modified: 30 Apr 2014 19:39
DOI: 10.6092/UNINA/FEDOA/4003


The NF-B2 gene is recurrently mutated and over-expressed in human lymphoid malignancies. However, a casual relationship between NF-B2 mutation and lymphomagenesis has not been established. It is also unclear how the mutation may lead to lymphoid malignancies. Recent studies suggest that nuclear factor B inducing kinase (NIK) is suppressed through constitutive proteasome-mediated degradation regulated by TRAF3, thus preventing processing of the NF-B2 precursor protein p100 to release p52. Here we demonstrate that BAFF Receptor, a member of the TNF Receptor family, interact with TRAF1, a member of TRAF family. This interaction activates NF-B2 via increased degradation of TRAF3 and stabilization of NIK. Indeed, interference of TRAF1 in lymphoma B cell line downregulates p100 processing and lead to decreased survival of B cells.

Actions (login required)

View Item View Item