Genetical, Immunological and Clinical Aspects of Inflammatory Gastrointestinal Disorders in Chilhood

Quaglietta, Lucia (2009) Genetical, Immunological and Clinical Aspects of Inflammatory Gastrointestinal Disorders in Chilhood. [Tesi di dottorato] (Inedito)

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Abstract

CONCLUSIONS This thesis aimed to define the genetical, immunological and clinical aspects of gastrointestinal inflammatory diseases in pediatrics, with attention to Inflammatory bowel disease (CD and UC) and to Eosinophilic Esophagitis (EoE). The following results were obtained and reported: 1) The characterization of mice with gut specific expression of Interleukin-12 (IL-12) family genes and their susceptibility to experimental colitis; 2) The role of Interleukin-23 receptor (IL-23R) Gene in Pediatric-Onset IBD and Genotype- Phenotype association in a pediatric population affected by IBD; 3) In order to find non invasive and offer the best therapeutical approach to patients affected by IBD we investigated the intestinal permeability test and we found that altered intestinal permeability study is predictive of early relapse in children with steroid responsive UC. 4) Then, we tried to obtain himmunoistochemical markers of small bowel inflammation in children with ulcerative colitis. We demonstrated that the density of CD25+ mononuclear cells is increase in jejunal mucosa of IBD patients, even in absence of gross endoscopic and histopathological abnormalities. 5) We also investigated the new terapeutical approach for IBD. We evaluated the effect of probiotics (VSL#3) on Induction and manteinance of remission in Children with Ulcerative colitis. 6) Finally, we riserve the last chapter of the thesis to EoE, an emerging disease in childhood: the EoE. We describe patients affected by celiac disease that also show the histological pattern of EoE. The unexpectedly high prevalence of CD in this EoE affected population and the probability of an association between gluten-induced disease and EoE prompted us to report these patients.

Tipologia di documento:Tesi di dottorato
Parole chiave:inflammatory bowel disease, eosinophilic esophagitis
Settori scientifico-disciplinari MIUR:Area 06 Scienze mediche > MED/38 PEDIATRIA GENERALE E SPECIALISTICA
Coordinatori della Scuola di dottorato:
Coordinatore del Corso di dottoratoe-mail (se nota)
Pignata, Claudio
Tutor della Scuola di dottorato:
Tutor del Corso di dottoratoe-mail (se nota)
Troncone, Riccardotroncone@unina.it
Stato del full text:Accessibile
Data:30 Novembre 2009
Numero di pagine:279
Istituzione:Università di Napoli "Federico II"
Dipartimento o Struttura:Dip.di Pediatria
Tipo di tesi:Dottorato
Stato dell'Eprint:Inedito
Scuola di dottorato:Scuola di Dottorato in Medicina Clinica e Sperimentale
Denominazione del dottorato:Riproduzione, Sviluppo e Accrescimento dell'Uomo
Ciclo di dottorato:XXII
Numero di sistema:4297
Depositato il:02 Dicembre 2009 14:28
Ultima modifica:28 Luglio 2010 12:46

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