Cipolletta, Daniela (2010) A LIAISON BETWEEN THE IMMUNE AND METABOLIC SYSTEMS: FAT REGULATORY T CELLS. [Tesi di dottorato] (Inedito)
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | A LIAISON BETWEEN THE IMMUNE AND METABOLIC SYSTEMS: FAT REGULATORY T CELLS |
| Autori: | Autore Email Cipolletta, Daniela danielacipolletta@libero.it |
| Data: | 30 Gennaio 2010 |
| Numero di pagine: | 119 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Istituzioni (extra): | CEINGE Biotecnologie Avanzate |
| Dipartimento: | CEINGE Biotecnologie avanzate |
| Scuola di dottorato: | SEMM – European School of Molecular Medicine |
| Dottorato: | PhD in Molecular Medicine (Molecular Oncology or Human Genetics) |
| Ciclo di dottorato: | 21 |
| Coordinatore del Corso di dottorato: | nome email Salvatore, Francesco salvator@unina.it |
| Tutor: | nome email Cortese, Riccardo cortese@ceinge.unina.it Russo, Tommaso tommaso.russo@unina.it Mathis, Diane dm@joslin.harvard.edu |
| Data: | 30 Gennaio 2010 |
| Numero di pagine: | 119 |
| Parole chiave: | Fat Regulatory T cells |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/11 - Malattie dell'apparato cardiovascolare Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare Area 06 - Scienze mediche > MED/04 - Patologia generale |
| Informazioni aggiuntive: | Ciclo III/XXI, Curriculum: Molecular Oncology |
| Depositato il: | 05 Feb 2010 16:16 |
| Ultima modifica: | 14 Gen 2015 12:10 |
| URI: | http://www.fedoa.unina.it/id/eprint/4317 |
Abstract
Obesity is characterized by low-grade inflammation of adipose tissue, which promotes insulin resistance and type-2 diabetes. Previous studies have highlighted the role of inflammatory macrophages in the onset of insulin resistance secondary to obesity. Here we explored the role of other players of the immune system in fat inflammation that normally are responsible for guarding against run-away auto-immunity, T regulatory cells. Regulatory CD4+ T cells that express the transcription factor Foxp3 (termed Tregs) are a lymphocyte lineage specialized in controlling immune responses. We report that Tregs with a unique phenotype are highly enriched in the abdominal fat of normal mice, but are strikingly and specifically reduced in insulin-resistant models of obesity. Loss-of-function and gain-of-function experiments demonstrated that Tregs regulate the inflammatory state of adipose tissue as well as insulin resistance. Cytokines differentially synthesized by fat-resident regulatory and conventional T cells directly impacted the synthesis of inflammatory mediators and glucose uptake by cultured adipocytes. In summary, we described a population of tissue specialized Treg cells that may modulate neighboring cells in potentially pathological contexts, which opens the door to harnessing their anti-inflammatory properties to inhibit elements of the metabolic syndrome.
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