Quantification of cerebral tissue volumes in multiple sclerosis: global and regional analysis

Prinster, Anna (2006) Quantification of cerebral tissue volumes in multiple sclerosis: global and regional analysis. [Tesi di dottorato] (Inedito)

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Abstract

Brain atrophy has been reported in multiple sclerosis (MS). We addressed the question of GM and WM tissue loss in a large population of 597 patients with multiple sclerosis (MS) compared with 104 control subjects using a fully automated, operator-independent, multiparametric segmentation method. Significant differences between patients with MS and control subjects included reduced fWM and fGM. MRI data showed significant differences between patients with relapsing–remitting and secondary progressive forms of MS: secondary progressive patients have significantly more atrophy of both WM and GM than do relapsing–remitting patients and a significantly higher lesion load. Significant correlations between MRI parameters and between MRI and clinical data were found. Moreover we addressed the question of if and where GM loss is localized by means of optimized Voxel-Based Morphometry applied to MRI studies of 51 patients with clinically defined Relapsing-Remitting MS and 34 age-matched normal subjects. In RR-MS patients, GM volume was significantly decreased at the level of the left fronto-temporal cortex and precuneus, as well as of anterior cingulate gyrus and of caudate nuclei bilaterally. The only cortical region of significant GM loss in the right hemisphere was located in the postcentral area. Our findings suggest that in RR-MS cortical GM reduction preferentially involves left fronto-temporal structures and deep GM, the latter correlating preferentially to global lesion load.

Tipologia di documento:Tesi di dottorato
Parole chiave:Multiple Sclerosis, MRI segmentation, Atrophy
Settori scientifico-disciplinari MIUR:Area 06 Scienze mediche > MED/36 DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
Coordinatori della Scuola di dottorato:
Coordinatore del Corso di dottoratoe-mail (se nota)
Annunziato, Lucio
Tutor della Scuola di dottorato:
Tutor del Corso di dottoratoe-mail (se nota)
Alfano, Bruno
Stato del full text:Accessibile
Data:2006
Numero di pagine:93
Istituzione:Università degli Studi di Napoli Federico II
Dipartimento o Struttura:Neuroscienze e Scienze del Comportamento
Tipo di tesi:Dottorato
Stato dell'Eprint:Inedito
Denominazione del dottorato:Neuroscienze e Patologia dell’Invecchiamento Cerebrale
Ciclo di dottorato:XVII
Numero di sistema:737
Depositato il:31 Luglio 2008
Ultima modifica:04 Febbraio 2009 09:39

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