Insabato, Luigi and Quarto, Maria and Riccio, Patrizia and Condorelli, Gerolama
(2009)
Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors.
[Pubblicazione in rivista scientifica]
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Tipologia del documento: |
Pubblicazione in rivista scientifica
|
Lingua: |
English |
Titolo: |
Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors. |
Autori: |
Autore | Email |
---|
Insabato, Luigi | [non definito] | Quarto, Maria | [non definito] | Riccio, Patrizia | [non definito] | Condorelli, Gerolama | [non definito] |
|
Autore/i: |
Insabato L., Amelio I., Quarto M., Zannetti A., Tolino F., de Mauro G., Cerchia L., Riccio P., Baumhoer D., Condorelli G., Terracciano L., de Franciscis V. |
Data: |
2009 |
Numero di pagine: |
7 |
Dipartimento: |
Scienze fisiche |
URL ufficiale: |
http://content.karger.com/produktedb/produkte.asp?... |
Titolo del periodico: |
ONCOLOGY |
Data: |
2009 |
Volume: |
77 |
Numero: |
6 |
Intervallo di pagine: |
pp. 378-384 |
Numero di pagine: |
7 |
[error in script]
[error in script]
Depositato il: |
21 Ott 2010 06:57 |
Ultima modifica: |
30 Apr 2014 19:43 |
URI: |
http://www.fedoa.unina.it/id/eprint/7498 |

Abstract
OBJECTIVES: Protein tyrosine phosphatases are key regulators of intracellular signaling that contribute to determining cancer cell growth, which thus makes them attractive targets for therapeutic and diagnostic agents. SHP-1 phosphotyrosine phosphatase is rarely expressed in epithelial tumor cells, but expression has been found in several breast cancer cell lines and tumors. To determine the potential significance of SHP-1 as a prognostic marker in the clinical setting, we examined SHP-1 protein expression in breast tumors. METHODS: We analyzed SHP-1 expression by immunohistochemistry in a breast tissue microarray composed of 2,081 cores, either alone or in combination with known prognostic markers. RESULTS: Our data showed that SHP-1 expression was confined to a well-defined subset of high-grade tumors characterized by unique biological parameters. SHP-1 expression correlated directly with expression of the tyrosine kinase receptor HER-2 and inversely with expression of the estrogen receptor, while it was weakly associated with Bcl-2 expression. CONCLUSIONS: Levels of SHP-1 were correlated with conventional pathologic parameters of tumor aggressiveness and were associated with reduced patient survival, suggesting that elevated expression of SHP-1 is a common molecular abnormality in a defined subset of breast tumors and might be used in routine diagnosis to identify patients with high-risk tumors.
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