Genome-wide scan for signatures of human population differentiation and their relationship with natural selection, functional pathways and diseases.

AMATO, ROBERTO and PINELLI, MICHELE and MIELE, GENNARO and COCOZZA, SERGIO (2009) Genome-wide scan for signatures of human population differentiation and their relationship with natural selection, functional pathways and diseases. [Pubblicazione su rivista scientifica]

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Abstract

Genetic differences both between individuals and populations are studied for their evolutionary relevance and for their potential medical applications. Most of the genetic differentiation among populations are caused by random drift that should affect all loci across the genome in a similar manner. When a locus shows extraordinary high or low levels of population differentiation, this may be interpreted as evidence for natural selection. The most used measure of population differentiation was devised by Wright and is known as fixation index, or FST. We performed a genome-wide estimation of FST on about 4 millions of SNPs from HapMap project data. We demonstrated a heterogeneous distribution of FST values between autosomes and heterochromosomes. When we compared the FST values obtained in this study with another evolutionary measure obtained by comparative interspecific approach, we found that genes under positive selection appeared to show low levels of population differentiation. We applied a gene set approach, widely used for microarray data analysis, to detect functional pathways under selection. We found that one pathway related to antigen processing and presentation showed low levels of FST, while several pathways related to cell signalling, growth and morphogenesis showed high FST values. Finally, we detected a signature of selection within genes associated with human complex diseases. These results can help to identify which process occurred during human evolution and adaptation to different environments. They also support the hypothesis that common diseases could have a genetic background shaped by human evolution.

Tipologia di documento:Pubblicazione su rivista scientifica
Settori scientifico-disciplinari MIUR:Non specificato
Stato del full text:Accessibilità ristretta
Data:2009
Altri Autori:Amato R., Pinelli M., Monticelli A., Marino D., Miele G., Cocozza S.
Numero di pagine:8
Intervallo di pagina:pp. 1-8
Volume:4
Dipartimento o Struttura:Dipartimento di Scienze Fisiche
Numero identificativo:10.1371/journal.pone.0007927
Titolo rivista/pubblicazione:PLOS ONE
Numero di sistema:7531
Depositato il:21 Ottobre 2010 08:57
Ultima modifica:21 Ottobre 2010 08:57

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