Autiero, Maddalena and Laccetti, Paolo and Marotta, Marcello and Quarto, Maria and Riccio, Patrizia and Roberti, Giuseppe (2009) Hematoporphyrin-mediated fluorescence reflectance imaging: application to early tumor detection in vivo in small animals. [Pubblicazione in rivista scientifica]

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Item Type: Pubblicazione in rivista scientifica
Language: English
Title: Hematoporphyrin-mediated fluorescence reflectance imaging: application to early tumor detection in vivo in small animals.
Creators:
CreatorsEmail
Autiero, MaddalenaUNSPECIFIED
Laccetti, PaoloUNSPECIFIED
Marotta, MarcelloUNSPECIFIED
Quarto, MariaUNSPECIFIED
Riccio, PatriziaUNSPECIFIED
Roberti, GiuseppeUNSPECIFIED
Autor/s: Autiero M., Cozzolino R., Laccetti P., Marotta M., Quarto M., Riccio P., Roberti G.
Date: 2009
Number of Pages: 6
Department: Scienze fisiche
Identification Number: 10.1007/s10103-007-0523-1
Official URL: http://www.springerlink.com/content/r2121142720347...
Journal or Publication Title: LASERS IN MEDICAL SCIENCE
Date: 2009
Volume: 24
Number: 2
Page Range: pp. 284-289
Number of Pages: 6
Uncontrolled Keywords: Hematoporphyrins, Tumor, Fluorescence, Lasers, Early diagnosis
Identification Number: 10.1007/s10103-007-0523-1
Date Deposited: 21 Oct 2010 06:57
Last Modified: 30 Apr 2014 19:43
URI: http://www.fedoa.unina.it/id/eprint/7616

Abstract

The in vivo early detection of subcutaneous human tumors implanted in small animals was studied by laser-induced fluorescence reflectance imaging (FRI), with a hematoporphyrin (HP) compound as an exogenous optical contrast agent. Tumor detection was shown to be possible just 3 days after the inoculation of tumor cells, when tumors were neither visible nor palpable. However, this detection capability is limited to a temporal window of approximately 100 h from HP administration and to a low optical contrast of the tumor (<2).

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