Hematoporphyrin-mediated fluorescence reflectance imaging: application to early tumor detection in vivo in small animals.
AUTIERO, MADDALENA and LACCETTI, PAOLO and MAROTTA, MARCELLO and QUARTO, MARIA and RICCIO, PATRIZIA and ROBERTI, GIUSEPPE (2009) Hematoporphyrin-mediated fluorescence reflectance imaging: application to early tumor detection in vivo in small animals. [Pubblicazione su rivista scientifica]
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The in vivo early detection of subcutaneous human tumors implanted in small animals was studied by laser-induced fluorescence reflectance imaging (FRI), with a hematoporphyrin (HP) compound as an exogenous optical contrast agent. Tumor detection was shown to be possible just 3 days after the inoculation of tumor cells, when tumors were neither visible nor palpable. However, this detection capability is limited to a temporal window of approximately 100 h from HP administration and to a low optical contrast of the tumor (<2).
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