Autiero, Maddalena and Laccetti, Paolo and Marotta, Marcello and Quarto, Maria and Riccio, Patrizia and Roberti, Giuseppe (2009) Hematoporphyrin-mediated fluorescence reflectance imaging: application to early tumor detection in vivo in small animals. [Pubblicazione in rivista scientifica]

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Item Type:	Pubblicazione in rivista scientifica
Lingua:	English
Title:	Hematoporphyrin-mediated fluorescence reflectance imaging: application to early tumor detection in vivo in small animals.
Creators:	Creators Email Autiero, Maddalena UNSPECIFIED Laccetti, Paolo UNSPECIFIED Marotta, Marcello UNSPECIFIED Quarto, Maria UNSPECIFIED Riccio, Patrizia UNSPECIFIED Roberti, Giuseppe UNSPECIFIED
Autore/i:	Autiero M., Cozzolino R., Laccetti P., Marotta M., Quarto M., Riccio P., Roberti G.
Date:	2009
Number of Pages:	6
Department:	Scienze fisiche
Identification Number:	10.1007/s10103-007-0523-1
Official URL:	http://www.springerlink.com/content/r2121142720347...
Journal or Publication Title:	LASERS IN MEDICAL SCIENCE
Date:	2009
Volume:	24
Number:	2
Page Range:	pp. 284-289
Number of Pages:	6
Uncontrolled Keywords:	Hematoporphyrins, Tumor, Fluorescence, Lasers, Early diagnosis
Identification Number:	10.1007/s10103-007-0523-1
Date Deposited:	21 Oct 2010 06:57
Last Modified:	30 Apr 2014 19:43
URI:	http://www.fedoa.unina.it/id/eprint/7616

Abstract

The in vivo early detection of subcutaneous human tumors implanted in small animals was studied by laser-induced fluorescence reflectance imaging (FRI), with a hematoporphyrin (HP) compound as an exogenous optical contrast agent. Tumor detection was shown to be possible just 3 days after the inoculation of tumor cells, when tumors were neither visible nor palpable. However, this detection capability is limited to a temporal window of approximately 100 h from HP administration and to a low optical contrast of the tumor (<2).

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