Giustiniano, Mariateresa (2010) Experiencing multi-component reactions: from post-condensation modifications to chemical platform and substrate design concepts. [Tesi di dottorato] (Inedito)
Anteprima |
PDF
Giustiniano_Mariateresa_23.pdf Download (4MB) | Anteprima |
| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | Experiencing multi-component reactions: from post-condensation modifications to chemical platform and substrate design concepts. |
| Autori: | Autore Email Giustiniano, Mariateresa mariateresagiustiniano@unina.it |
| Data: | 27 Novembre 2010 |
| Numero di pagine: | 147 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Chimica farmaceutica e tossicologica |
| Scuola di dottorato: | Scienze farmaceutiche |
| Dottorato: | Scienza del farmaco |
| Ciclo di dottorato: | 23 |
| Coordinatore del Corso di dottorato: | nome email D'Auria, Maria Valeria madauria@unina.it |
| Tutor: | nome email Novellino, Ettore novellin@unina.it |
| Data: | 27 Novembre 2010 |
| Numero di pagine: | 147 |
| Parole chiave: | multi-component reactions;domino processes |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/08 - Chimica farmaceutica |
| Depositato il: | 14 Dic 2010 10:25 |
| Ultima modifica: | 30 Apr 2014 19:44 |
| URI: | http://www.fedoa.unina.it/id/eprint/8015 |
| DOI: | 10.6092/UNINA/FEDOA/8015 |
Abstract
The following thesis dealt with the study of new MCRs identification and the development of new MCR/ post-condensation transformations sequences. As post-MCR modifications two sequences have been studied: a Passerini 3-CR/Buchwald cyclization in order to get benzooxazepines and an Ugi-like/ debenzylation/ transamination reaction affording 1-aryl-5-aroyl tetrazoles. These latter compounds underwent pharmacological investigation as potential chalcones biomimetics. In the second part of the thesis, dealing with new MCRs identification, the attempted synthesis of functionalized isocyanides has been described based on the “substrate design” principle, followed by the application of “chemical platform” concept to oxadiazoles in order to get bicyclofurans through an Ugi-Aza Wittig/ (amidation)/ Diels-Alder cycloaddition domino process
Downloads
Downloads per month over past year
Actions (login required)
 |
Modifica documento |
