Giustiniano, Mariateresa (2010) Experiencing multi-component reactions: from post-condensation modifications to chemical platform and substrate design concepts. [Tesi di dottorato] (Inedito)

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Tipologia del documento: Tesi di dottorato
Lingua: English
Titolo: Experiencing multi-component reactions: from post-condensation modifications to chemical platform and substrate design concepts.
Autori:
AutoreEmail
Giustiniano, Mariateresamariateresagiustiniano@unina.it
Data: 27 Novembre 2010
Numero di pagine: 147
Istituzione: Università degli Studi di Napoli Federico II
Dipartimento: Chimica farmaceutica e tossicologica
Scuola di dottorato: Scienze farmaceutiche
Dottorato: Scienza del farmaco
Ciclo di dottorato: 23
Coordinatore del Corso di dottorato:
nomeemail
D'Auria, Maria Valeriamadauria@unina.it
Tutor:
nomeemail
Novellino, Ettorenovellin@unina.it
Data: 27 Novembre 2010
Numero di pagine: 147
Parole chiave: multi-component reactions;domino processes
Settori scientifico-disciplinari del MIUR: Area 03 - Scienze chimiche > CHIM/08 - Chimica farmaceutica
Depositato il: 14 Dic 2010 10:25
Ultima modifica: 30 Apr 2014 19:44
URI: http://www.fedoa.unina.it/id/eprint/8015
DOI: 10.6092/UNINA/FEDOA/8015

Abstract

The following thesis dealt with the study of new MCRs identification and the development of new MCR/ post-condensation transformations sequences. As post-MCR modifications two sequences have been studied: a Passerini 3-CR/Buchwald cyclization in order to get benzooxazepines and an Ugi-like/ debenzylation/ transamination reaction affording 1-aryl-5-aroyl tetrazoles. These latter compounds underwent pharmacological investigation as potential chalcones biomimetics. In the second part of the thesis, dealing with new MCRs identification, the attempted synthesis of functionalized isocyanides has been described based on the “substrate design” principle, followed by the application of “chemical platform” concept to oxadiazoles in order to get bicyclofurans through an Ugi-Aza Wittig/ (amidation)/ Diels-Alder cycloaddition domino process

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