Giustiniano, Mariateresa
(2010)
Experiencing multi-component reactions: from post-condensation modifications to chemical platform and substrate design concepts.
[Tesi di dottorato]
(Unpublished)
| Item Type: |
Tesi di dottorato
|
| Resource language: |
English |
| Title: |
Experiencing multi-component reactions: from post-condensation modifications to chemical platform and substrate design concepts. |
| Creators: |
| Creators | Email |
|---|
| Giustiniano, Mariateresa | mariateresagiustiniano@unina.it |
|
| Date: |
27 November 2010 |
| Number of Pages: |
147 |
| Institution: |
Università degli Studi di Napoli Federico II |
| Department: |
Chimica farmaceutica e tossicologica |
| Scuola di dottorato: |
Scienze farmaceutiche |
| Dottorato: |
Scienza del farmaco |
| Ciclo di dottorato: |
23 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| D'Auria, Maria Valeria | madauria@unina.it |
|
| Tutor: |
| nome | email |
|---|
| Novellino, Ettore | novellin@unina.it |
|
| Date: |
27 November 2010 |
| Number of Pages: |
147 |
| Keywords: |
multi-component reactions;domino processes |
| Settori scientifico-disciplinari del MIUR: |
Area 03 - Scienze chimiche > CHIM/08 - Chimica farmaceutica |
[error in script]
[error in script]
| Date Deposited: |
14 Dec 2010 10:25 |
| Last Modified: |
30 Apr 2014 19:44 |
| URI: |
http://www.fedoa.unina.it/id/eprint/8015 |
| DOI: |
10.6092/UNINA/FEDOA/8015 |
Collection description
The following thesis dealt with the study of new MCRs identification and the development of new MCR/ post-condensation transformations sequences. As post-MCR modifications two sequences have been studied: a Passerini 3-CR/Buchwald cyclization in order to get benzooxazepines and an Ugi-like/ debenzylation/ transamination reaction affording 1-aryl-5-aroyl tetrazoles. These latter compounds underwent pharmacological investigation as potential chalcones biomimetics. In the second part of the thesis, dealing with new MCRs identification, the attempted synthesis of functionalized isocyanides has been described based on the “substrate design” principle, followed by the application of “chemical platform” concept to oxadiazoles in order to get bicyclofurans through an Ugi-Aza Wittig/ (amidation)/ Diels-Alder cycloaddition domino process
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