Giustiniano, Mariateresa (2010) Experiencing multi-component reactions: from post-condensation modifications to chemical platform and substrate design concepts. [Tesi di dottorato] (Unpublished)

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Item Type: Tesi di dottorato
Language: English
Title: Experiencing multi-component reactions: from post-condensation modifications to chemical platform and substrate design concepts.
Creators:
CreatorsEmail
Giustiniano, Mariateresamariateresagiustiniano@unina.it
Date: 27 November 2010
Number of Pages: 147
Institution: Università degli Studi di Napoli Federico II
Department: Chimica farmaceutica e tossicologica
Doctoral School: Scienze farmaceutiche
PHD name: Scienza del farmaco
PHD cycle: 23
PHD Coordinator:
nameemail
D'Auria, Maria Valeriamadauria@unina.it
Tutor:
nameemail
Novellino, Ettorenovellin@unina.it
Date: 27 November 2010
Number of Pages: 147
Uncontrolled Keywords: multi-component reactions;domino processes
MIUR S.S.D.: Area 03 - Scienze chimiche > CHIM/08 - Chimica farmaceutica
Date Deposited: 14 Dec 2010 10:25
Last Modified: 30 Apr 2014 19:44
URI: http://www.fedoa.unina.it/id/eprint/8015

Abstract

The following thesis dealt with the study of new MCRs identification and the development of new MCR/ post-condensation transformations sequences. As post-MCR modifications two sequences have been studied: a Passerini 3-CR/Buchwald cyclization in order to get benzooxazepines and an Ugi-like/ debenzylation/ transamination reaction affording 1-aryl-5-aroyl tetrazoles. These latter compounds underwent pharmacological investigation as potential chalcones biomimetics. In the second part of the thesis, dealing with new MCRs identification, the attempted synthesis of functionalized isocyanides has been described based on the “substrate design” principle, followed by the application of “chemical platform” concept to oxadiazoles in order to get bicyclofurans through an Ugi-Aza Wittig/ (amidation)/ Diels-Alder cycloaddition domino process

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