Corso, Carmela
(2010)
Identificazione di proteine con attività di legame agli mRNA degli antigeni MHC di classe II.
[Tesi di dottorato]
(Unpublished)
| Item Type: |
Tesi di dottorato
|
| Lingua: |
Italiano |
| Title: |
Identificazione di proteine con attività di legame agli mRNA degli antigeni MHC di classe II |
| Creators: |
| Creators | Email |
|---|
| Corso, Carmela | carmelacorso@libero.it |
|
| Date: |
28 November 2010 |
| Number of Pages: |
83 |
| Institution: |
Università degli Studi di Napoli Federico II |
| Department: |
Biologia strutturale e funzionale |
| Scuola di dottorato: |
Scienze biologiche |
| Dottorato: |
Biologia applicata |
| Ciclo di dottorato: |
23 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| Ricca, Ezio | ezio.ricca@unina.it |
|
| Tutor: |
| nome | email |
|---|
| Abrescia, Paolo | paolo.abrescia@unina.it |
|
| Date: |
28 November 2010 |
| Number of Pages: |
83 |
| Uncontrolled Keywords: |
MHC di classe II; regolazione post-trascrizionale; RNA binding proteins; RNA operone |
| Settori scientifico-disciplinari del MIUR: |
Area 05 - Scienze biologiche > BIO/09 - Fisiologia |
[error in script]
[error in script]
| Date Deposited: |
02 Dec 2010 10:46 |
| Last Modified: |
30 Apr 2014 19:44 |
| URI: |
http://www.fedoa.unina.it/id/eprint/8039 |
| DOI: |
10.6092/UNINA/FEDOA/8039 |
Abstract
Major Histocompatibility Complex class II mRNAs encode heterodimeric proteins involved in the
presentation of exogenous antigens during immune response. Their 3'UTRs bind a protein complex
in which we identified two factors: EBP1, an Erb3 receptor-binding protein, and DRBP76, a
double-stranded RNA-binding Nuclear Protein, also known as Nuclear Factor 90. Both are well
characterized regulatory factors of several mRNA molecules processing. Using either EBP1 or
DRBP76/NF90 specific knockdown experiments, we established that the two proteins play a role in
regulating the expression of HLA-DRA, HLA-DRB1 and HLA-DQA1 mRNAs levels. Our study
represents the first indication of the existence of a functional unit that includes different transcripts
involved in the adaptive immune response. We propose that the concept of “RNA operon” may be
suitable for our system in which MHCII mRNAs are modulated via interaction of their 3’UTR with
same proteins.
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