Arzillo, Marianna (2010) INTEGRATED COMPUTATIONAL/EXPERIMENTAL APPROACHES TO THE STUDY OF THE OXIDATIVE CHEMISTRY OF PHENOLIC SYSTEMS. [Tesi di dottorato] (Unpublished)
Preview |
PDF
Arzillo_Marianna_23.pdf Download (6MB) | Preview |
| Item Type: | Tesi di dottorato |
|---|---|
| Resource language: | English |
| Title: | INTEGRATED COMPUTATIONAL/EXPERIMENTAL APPROACHES TO THE STUDY OF THE OXIDATIVE CHEMISTRY OF PHENOLIC SYSTEMS |
| Creators: | Creators Email Arzillo, Marianna marianna.arzillo@unina.it |
| Date: | 29 November 2010 |
| Number of Pages: | 202 |
| Institution: | Università degli Studi di Napoli Federico II |
| Department: | Chimica "Paolo Corradini" |
| Scuola di dottorato: | Scienze chimiche |
| Dottorato: | Scienze chimiche |
| Ciclo di dottorato: | 23 |
| Coordinatore del Corso di dottorato: | nome email Previtera, Lucio previter@unina.it |
| Tutor: | nome email Crescenzi, Orlando orlando.crescenzi@unina.it |
| Date: | 29 November 2010 |
| Number of Pages: | 202 |
| Keywords: | 5,6-dihydroxyindole, eumelanin, DFT |
| Settori scientifico-disciplinari del MIUR: | Area 03 - Scienze chimiche > CHIM/02 - Chimica fisica |
| Date Deposited: | 02 Dec 2010 07:54 |
| Last Modified: | 30 Apr 2014 19:44 |
| URI: | http://www.fedoa.unina.it/id/eprint/8100 |
| DOI: | 10.6092/UNINA/FEDOA/8100 |
Collection description
5,6-Dihydroxyindole belongs to a unique group of naturally occurring indole compounds which have intrigued generations of organic and natural product chemists because of their central role in the biosynthesis of eumelanins, the major determinants of human skin, hair and eye pigmentation. The unique status of eumelanins among natural pigments is due to their socio-economic and biomedical relevance, encompassing racial pigmentation, skin photoprotection, sun tanning and pigmentary disorders such as albinism, vitiligo and melanoma. Despite many decades of work within the organic chemistry, biophysics and pigment cell communities, eumelanin structure remains virtually unknown, because of the marked chemical heterogeneity and the lack of well defined physicochemical properties, preventing successful application of spectroscopic techniques. In the present thesis, the chemistry of 5,6-dihydroxyindole has been investigated by combining and integrating the information provided by computational and experimental methodologies. This approach has proved useful to address and settle many open issues concerning the mechanisms of oxidative polymerization of 5,6-dihydroxyindoles and the basic features of eumelanin builiding blocks.
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |
