Malara, Angela Eliana (2010) Effects of three different anti-ErbB2 antibodies on prostate tumors. [Tesi di dottorato] (Unpublished)

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Item Type: Tesi di dottorato
Language: English
Title: Effects of three different anti-ErbB2 antibodies on prostate tumors
Creators:
CreatorsEmail
Malara, Angela Elianaeliana.malara@unina.it
Date: 29 November 2010
Number of Pages: 30
Institution: Università degli Studi di Napoli Federico II
Department: Biologia strutturale e funzionale
Doctoral School: Scienze biologiche
PHD name: Biochimica e biologia cellulare e molecolare
PHD cycle: 23
PHD Coordinator:
nameemail
Arcari, Paoloarcari@unina.it
Tutor:
nameemail
De Lorenzo, Claudiacladelo@unina.it
Date: 29 November 2010
Number of Pages: 30
Uncontrolled Keywords: ErbB2-Prostate cancer
MIUR S.S.D.: Area 05 - Scienze biologiche > BIO/10 - Biochimica
Date Deposited: 09 Dec 2010 16:49
Last Modified: 17 Jun 2014 06:02
URI: http://www.fedoa.unina.it/id/eprint/8140

Abstract

Prostate cancer is the most commonly diagnosed malignancy in men in developed countries. ErbB2 contributes to prostate cancer progression by activating the androgen receptor in a steroid poor environment, thus promoting androgen-independent cell growth and survival. The consequent development of hormone refractory tumors is a major obstacle in prostate cancer therapy. The inhibition of ErbB2 signal transduction pathways by the use of human antibodies has been considered as a valuable alternative strategy for cancer therapy. Herein we report a comparative analysis of the antitumor effects of three different antibodies targeting different epitopes of ErbB2: Herceptin (Trastuzumab), 2C4 (Pertuzumab), and Erb-hcAb, a novel fully human compact antibody produced in our laboratory. We demonstrate that the in vitro and in vivo growth of both androgen- dependent and –independent prostate cancer cells is efficiently inhibited by Erb-hcAb, which shows antitumor effects on some cell lines more potent than those observed for either Herceptin or 2C4

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