Malara, Angela Eliana
(2010)
Effects of three different anti-ErbB2 antibodies on prostate tumors.
[Tesi di dottorato]
(Unpublished)
| Item Type: |
Tesi di dottorato
|
| Lingua: |
English |
| Title: |
Effects of three different anti-ErbB2 antibodies on prostate tumors |
| Creators: |
| Creators | Email |
|---|
| Malara, Angela Eliana | eliana.malara@unina.it |
|
| Date: |
29 November 2010 |
| Number of Pages: |
30 |
| Institution: |
Università degli Studi di Napoli Federico II |
| Department: |
Biologia strutturale e funzionale |
| Scuola di dottorato: |
Scienze biologiche |
| Dottorato: |
Biochimica e biologia cellulare e molecolare |
| Ciclo di dottorato: |
23 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| Arcari, Paolo | arcari@unina.it |
|
| Tutor: |
| nome | email |
|---|
| De Lorenzo, Claudia | cladelo@unina.it |
|
| Date: |
29 November 2010 |
| Number of Pages: |
30 |
| Uncontrolled Keywords: |
ErbB2-Prostate cancer |
| Settori scientifico-disciplinari del MIUR: |
Area 05 - Scienze biologiche > BIO/10 - Biochimica |
[error in script]
[error in script]
| Date Deposited: |
09 Dec 2010 16:49 |
| Last Modified: |
17 Jun 2014 06:02 |
| URI: |
http://www.fedoa.unina.it/id/eprint/8140 |
Abstract
Prostate cancer is the most commonly diagnosed malignancy in men in developed countries. ErbB2 contributes to prostate cancer progression by activating the androgen receptor in a steroid poor environment, thus promoting androgen-independent cell growth and survival. The consequent development of hormone refractory tumors is a major obstacle in prostate cancer therapy.
The inhibition of ErbB2 signal transduction pathways by the use of human antibodies has been considered as a valuable alternative strategy for cancer therapy.
Herein we report a comparative analysis of the antitumor effects of three different antibodies targeting different epitopes of ErbB2: Herceptin (Trastuzumab), 2C4 (Pertuzumab), and Erb-hcAb, a novel fully human compact antibody produced in our laboratory.
We demonstrate that the in vitro and in vivo growth of both androgen- dependent and –independent prostate cancer cells is efficiently inhibited by Erb-hcAb, which shows antitumor effects on some cell lines more potent than those observed for either Herceptin or 2C4
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