Lembo, Serena (2010) IL-33 and keratinocytes: a trait d'union in innate immunity mechanisms of psoriasis. [Tesi di dottorato] (Inedito)
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| Tipologia del documento: | Tesi di dottorato |
|---|---|
| Lingua: | English |
| Titolo: | IL-33 and keratinocytes: a trait d'union in innate immunity mechanisms of psoriasis. |
| Autori: | Autore Email Lembo, Serena serenalembo@yahoo.it |
| Data: | 29 Novembre 2010 |
| Numero di pagine: | 29 |
| Istituzione: | Università degli Studi di Napoli Federico II |
| Dipartimento: | Patologia sistematica |
| Scuola di dottorato: | Medicina clinica e sperimentale |
| Dottorato: | Fisiopatologia clinica e medicina sperimentale |
| Ciclo di dottorato: | 23 |
| Coordinatore del Corso di dottorato: | nome email Marone, Gianni [non definito] |
| Tutor: | nome email Ayala, Fabio ayala@unina.it |
| Data: | 29 Novembre 2010 |
| Numero di pagine: | 29 |
| Parole chiave: | Psoriasis, interleukin-33 (IL-33), immunity |
| Settori scientifico-disciplinari del MIUR: | Area 06 - Scienze mediche > MED/35 - Malattie cutanee e veneree |
| Informazioni aggiuntive: | Per autorizzazione ricevuta dal Colleggio dei Docenti del Dottorato di Ricerca in Fisiopatologia Clinica e Medicina Sperimentale (XIII Ciclo), deposito la tesi in lingua inglese. |
| Depositato il: | 02 Dic 2010 12:16 |
| Ultima modifica: | 30 Apr 2014 19:45 |
| URI: | http://www.fedoa.unina.it/id/eprint/8246 |
Abstract
IL-33 is a pro-inflammatory cytokine recently identified as a ligand for the orphan receptor ST2. IL-33 constitutive nuclear expression has been found in cells of tissues exposed to the environment. Moreover endothelial cells have been shown to abundantly express IL-33. Many of the inflammatory effects of IL-33 define its ability to induce Th2-type mediated responses but recently IL-33 was found to have a pro-inflammatory role in arthritis, which is Th1 and/or Th17 mediated. It can be hypothesized that IL-33 has a pro-inflammatory role in psoriasis too. In the present study we aimed to assess the role of IL-33 in psoriasis, investigating its property to promote inflammation via MC and KC activation. Here we report that IL-33 is elevated in the skin of psoriasis patients. Furthermore, IL-33 upregulates IL-4 and IL-13 and is able to induce a higher increase of MCP-1 and VEGF respect to TNF-α in MCs. In presence of TNF-α, IL-33 induces MCP-1 and IL-6, whereas in association with IL-17, is able to induce IL-20 in KCs. In conclusion, our study provides evidence that IL-33 is involved in psoriasis biology. Furthermore, our results reinforce the IL-33 activity in driving Th1 response too, contributing to the maintenance of psoriasis pathogenesis.
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