Giannattasio, Giorgio (2010) THE P2Y6 RECEPTOR INHIBITS EFFECTOR T CELL ACTIVATION IN ALLERGIC PULMONARY INFLAMMATION. [Tesi di dottorato] (Inedito)

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Tipologia del documento: Tesi di dottorato
Lingua: English
Titolo: THE P2Y6 RECEPTOR INHIBITS EFFECTOR T CELL ACTIVATION IN ALLERGIC PULMONARY INFLAMMATION
Autori:
AutoreEmail
Giannattasio, Giorgiogiorgionap@yahoo.it
Data: 30 Novembre 2010
Numero di pagine: 74
Istituzione: Università degli Studi di Napoli Federico II
Dipartimento: Medicina clinica e scienze cardiovascolari e immunologiche
Scuola di dottorato: Medicina clinica e sperimentale
Dottorato: Fisiopatologia clinica e medicina sperimentale
Ciclo di dottorato: 23
Coordinatore del Corso di dottorato:
nomeemail
Marone, Giannimarone@unina.it
Tutor:
nomeemail
Marone, Giannimarone@unina.it
Data: 30 Novembre 2010
Numero di pagine: 74
Parole chiave: Purinergic receptor, Allergic inflammation, T cells
Settori scientifico-disciplinari del MIUR: Area 06 - Scienze mediche > MED/09 - Medicina interna
Depositato il: 03 Dic 2010 09:26
Ultima modifica: 30 Apr 2014 19:46
URI: http://www.fedoa.unina.it/id/eprint/8384
DOI: 10.6092/UNINA/FEDOA/8384

Abstract

We show that the P2Y6 receptor, a G-protein-coupled receptor with high affinity for the nucleotide uridine diphosphate, is an important endogenous inhibitor of T cell function in allergic pulmonary inflammation. Mice conditionally deficient in P2Y6 receptors [p2ry6 (flox/flox);cre/+ mice] exhibited severe airway and tissue pathology relative to P2Y6-sufficient [p2ry6 (flox/flox)] littermates (+/+ mice) when treated intranasally with an extract (Df) of the dust mite Dermatophagoides farinae. P2Y6 receptors were inducibly expressed by lung, lymph node and splenic CD4+ and CD8+ T cells of Df-treated +/+ mice. Df-restimulated P2Y6-deficient lymph node cells produced higher levels of Th1 and Th2 cytokines, and polyclonally-stimulated P2Y6-deficient CD4+ T cells proliferated faster than comparably stimulated P2Y6-sufficient cells. The absence of P2Y6 receptors on CD4+ cells, but not antigen presenting cells, was sufficient to amplify cytokine generation. Thus, P2Y6 receptors protect the lung against exuberant allergen-induced pulmonary inflammation by inhibiting the activation of effector T cells.

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