Giannattasio, Giorgio (2010) THE P2Y6 RECEPTOR INHIBITS EFFECTOR T CELL ACTIVATION IN ALLERGIC PULMONARY INFLAMMATION. [Tesi di dottorato] (Unpublished)

[img]
Preview
PDF
Giannattasio_Giorgio_23.pdf

Download (4MB) | Preview
Item Type: Tesi di dottorato
Language: English
Title: THE P2Y6 RECEPTOR INHIBITS EFFECTOR T CELL ACTIVATION IN ALLERGIC PULMONARY INFLAMMATION
Creators:
CreatorsEmail
Giannattasio, Giorgiogiorgionap@yahoo.it
Date: 30 November 2010
Number of Pages: 74
Institution: Università degli Studi di Napoli Federico II
Department: Medicina clinica e scienze cardiovascolari e immunologiche
Doctoral School: Medicina clinica e sperimentale
PHD name: Fisiopatologia clinica e medicina sperimentale
PHD cycle: 23
PHD Coordinator:
nameemail
Marone, Giannimarone@unina.it
Tutor:
nameemail
Marone, Giannimarone@unina.it
Date: 30 November 2010
Number of Pages: 74
Uncontrolled Keywords: Purinergic receptor, Allergic inflammation, T cells
MIUR S.S.D.: Area 06 - Scienze mediche > MED/09 - Medicina interna
Date Deposited: 03 Dec 2010 09:26
Last Modified: 30 Apr 2014 19:46
URI: http://www.fedoa.unina.it/id/eprint/8384

Abstract

We show that the P2Y6 receptor, a G-protein-coupled receptor with high affinity for the nucleotide uridine diphosphate, is an important endogenous inhibitor of T cell function in allergic pulmonary inflammation. Mice conditionally deficient in P2Y6 receptors [p2ry6 (flox/flox);cre/+ mice] exhibited severe airway and tissue pathology relative to P2Y6-sufficient [p2ry6 (flox/flox)] littermates (+/+ mice) when treated intranasally with an extract (Df) of the dust mite Dermatophagoides farinae. P2Y6 receptors were inducibly expressed by lung, lymph node and splenic CD4+ and CD8+ T cells of Df-treated +/+ mice. Df-restimulated P2Y6-deficient lymph node cells produced higher levels of Th1 and Th2 cytokines, and polyclonally-stimulated P2Y6-deficient CD4+ T cells proliferated faster than comparably stimulated P2Y6-sufficient cells. The absence of P2Y6 receptors on CD4+ cells, but not antigen presenting cells, was sufficient to amplify cytokine generation. Thus, P2Y6 receptors protect the lung against exuberant allergen-induced pulmonary inflammation by inhibiting the activation of effector T cells.

Actions (login required)

View Item View Item