Staiano, Leopoldo (2011) Thyroid-like function in the urochordate Ciona intestinalis. [Tesi di dottorato] (Unpublished)

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Item Type:	Tesi di dottorato
Resource language:	English
Title:	Thyroid-like function in the urochordate Ciona intestinalis
Creators:	Creators Email Staiano, Leopoldo leopoldo.staiano@szn.it
Date:	November 2011
Number of Pages:	129
Institution:	Università degli Studi di Napoli Federico II
Department:	Strutture, funzioni e tecnologie biologiche
Scuola di dottorato:	Scienze veterinarie per la produzione e la sanità
Dottorato:	Organismi modello nella ricerca biomedica e veterinaria
Ciclo di dottorato:	24
Coordinatore del Corso di dottorato:	nome email De Girolamo, Paolo degirola@unina.it
Tutor:	nome email Di Lauro, Roberto rdilauro@unina.it
Date:	November 2011
Number of Pages:	129
Keywords:	Ciona intestinalis, Endostyle, metamorphosis, Thyroid Hormones, Thyroid Hormone Receptor
Settori scientifico-disciplinari del MIUR:	Area 05 - Scienze biologiche > BIO/11 - Biologia molecolare Area 06 - Scienze mediche > MED/03 - Genetica medica Area 05 - Scienze biologiche > BIO/05 - Zoologia
Date Deposited:	09 Dec 2011 10:57
Last Modified:	30 Apr 2014 19:47
URI:	http://www.fedoa.unina.it/id/eprint/8656
DOI:	10.6092/UNINA/FEDOA/8656

Collection description

In the studies reported in the manuscript I investigated the involvement of Iodine and thyroxine (Thyroid Hormone, T4) in Ciona intestinalis metamorphosis. To date, the mechanisms regulating the metamorphosis of ascidians remain largely unknown. In vivo treatment of swimming larvae with exogenous L-thyroxine and goitrogens (methimazole, thiourea and Potassium Perchlorate), demonstrated the role that the intact thyroid hormone biosynthetic molecular machinery plays in the control of metamorphosis. I further supported the idea of a vertebrate-like thyroid function in tunicates, by reinforcing the phylogenetic link between thyroid gland and the endostyle organ through the identification, amongst the proteins extracted from Ciona endostyle, of a protein, CRELD, apparently not related to vertebrate thyroglobulin, that hypothetically could represent the scaffold for TH synthesis in Ciona intestinalis. My present studies have also demonstrated that the Ciona CiNR1, previously reported as inactive, is a functional thyroid receptor, further strengthening the idea that a thyroid function, comparable to that of vertebrates, is present also in tunicates.

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