Brancaccio, Diego
(2011)
Interaction of peptides and small molecules with biological targets.
[Tesi di dottorato]
(Unpublished)
| Item Type: |
Tesi di dottorato
|
| Resource language: |
English |
| Title: |
Interaction of peptides and small molecules with biological targets |
| Creators: |
| Creators | Email |
|---|
| Brancaccio, Diego | diego.brancaccio@unina.it |
|
| Date: |
30 November 2011 |
| Number of Pages: |
249 |
| Institution: |
Università degli Studi di Napoli Federico II |
| Department: |
Chimica farmaceutica e tossicologica |
| Scuola di dottorato: |
Scienze farmaceutiche |
| Dottorato: |
Scienza del farmaco |
| Ciclo di dottorato: |
24 |
| Coordinatore del Corso di dottorato: |
| nome | email |
|---|
| D'Auria, Maria Valeria | madauria@unina.it |
|
| Tutor: |
| nome | email |
|---|
| Carotenuto, Alfonso | alfonso.carotenuto@unina.it |
|
| Date: |
30 November 2011 |
| Number of Pages: |
249 |
| Keywords: |
NMR, peptide, conformational analysis |
| Settori scientifico-disciplinari del MIUR: |
Area 03 - Scienze chimiche > CHIM/08 - Chimica farmaceutica |
[error in script]
[error in script]
| Date Deposited: |
06 Dec 2011 11:27 |
| Last Modified: |
30 Apr 2014 19:48 |
| URI: |
http://www.fedoa.unina.it/id/eprint/8816 |
| DOI: |
10.6092/UNINA/FEDOA/8816 |
Collection description
During my PhD course, I focused my attention on the conformational analysis of peptides that interact with GPCR and ligand-receptor interactions from NMR spectroscopy with possible application to cytotoxic agents binding to DNA.
In particular, I investigated the conformational behaviour of peptide analogues of Urotensin, Melanocortin and Somatostatin in water solution and membrane mimetic environment (SDS and DPC micelles).
Another research field was the NMR-based screening as potent technique for the identification of small molecules that interact with macromolecule targets. Several methods based on the ligand observation have been proposed in the literature, among these WaterLOGSY (water-ligand observed via gradient spectroscopy), and STD-NMR (saturation transfer difference) experiments. I applied these NMR techniques for the evaluation of the DNA interactions of a new series of thiophen-naphthoquinones with interesting cytotoxic activity.
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